ANTsX neuroimaging-derived structural phenotypes of UK Biobank
- PMID: 38632390
- PMCID: PMC11024129
- DOI: 10.1038/s41598-024-59440-6
ANTsX neuroimaging-derived structural phenotypes of UK Biobank
Abstract
UK Biobank is a large-scale epidemiological resource for investigating prospective correlations between various lifestyle, environmental, and genetic factors with health and disease progression. In addition to individual subject information obtained through surveys and physical examinations, a comprehensive neuroimaging battery consisting of multiple modalities provides imaging-derived phenotypes (IDPs) that can serve as biomarkers in neuroscience research. In this study, we augment the existing set of UK Biobank neuroimaging structural IDPs, obtained from well-established software libraries such as FSL and FreeSurfer, with related measurements acquired through the Advanced Normalization Tools Ecosystem. This includes previously established cortical and subcortical measurements defined, in part, based on the Desikan-Killiany-Tourville atlas. Also included are morphological measurements from two recent developments: medial temporal lobe parcellation of hippocampal and extra-hippocampal regions in addition to cerebellum parcellation and thickness based on the Schmahmann anatomical labeling. Through predictive modeling, we assess the clinical utility of these IDP measurements, individually and in combination, using commonly studied phenotypic correlates including age, fluid intelligence, numeric memory, and several other sociodemographic variables. The predictive accuracy of these IDP-based models, in terms of root-mean-squared-error or area-under-the-curve for continuous and categorical variables, respectively, provides comparative insights between software libraries as well as potential clinical interpretability. Results demonstrate varied performance between package-based IDP sets and their combination, emphasizing the need for careful consideration in their selection and utilization.
© 2024. The Author(s).
Conflict of interest statement
The authors declare no competing interests.
Figures
Update of
-
ANTsX neuroimaging-derived structural phenotypes of UK Biobank.Res Sq [Preprint]. 2023 Oct 30:rs.3.rs-3459157. doi: 10.21203/rs.3.rs-3459157/v1. Res Sq. 2023. Update in: Sci Rep. 2024 Apr 17;14(1):8848. doi: 10.1038/s41598-024-59440-6. PMID: 37961236 Free PMC article. Updated. Preprint.
Similar articles
-
ANTsX neuroimaging-derived structural phenotypes of UK Biobank.Res Sq [Preprint]. 2023 Oct 30:rs.3.rs-3459157. doi: 10.21203/rs.3.rs-3459157/v1. Res Sq. 2023. Update in: Sci Rep. 2024 Apr 17;14(1):8848. doi: 10.1038/s41598-024-59440-6. PMID: 37961236 Free PMC article. Updated. Preprint.
-
Association between surgical admissions, cognition, and neurodegeneration in older people: a population-based study from the UK Biobank.Lancet Healthy Longev. 2024 Sep;5(9):100623. doi: 10.1016/j.lanhl.2024.07.006. Epub 2024 Sep 5. Lancet Healthy Longev. 2024. PMID: 39245058 Free PMC article.
-
Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads study.PLoS One. 2022 Sep 29;17(9):e0273704. doi: 10.1371/journal.pone.0273704. eCollection 2022. PLoS One. 2022. PMID: 36173949 Free PMC article.
-
Wellbeing and brain structure: A comprehensive phenotypic and genetic study of image-derived phenotypes in the UK Biobank.Hum Brain Mapp. 2022 Dec 1;43(17):5180-5193. doi: 10.1002/hbm.25993. Epub 2022 Jun 29. Hum Brain Mapp. 2022. PMID: 35765890 Free PMC article. Review.
-
[A review on the application of UK Biobank in neuroimaging].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021 Jun 25;38(3):594-601. doi: 10.7507/1001-5515.202012059. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021. PMID: 34180206 Free PMC article. Review. Chinese.
References
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources