Functions of Glycosylation and Related Web Resources for Its Prediction
- PMID: 35696078
- DOI: 10.1007/978-1-0716-2317-6_6
Functions of Glycosylation and Related Web Resources for Its Prediction
Abstract
Glycosylation involves the attachment of carbohydrate sugar chains, or glycans, onto an amino acid residue of a protein. These glycans are often branched structures and serve to modulate the function of proteins. Glycans are synthesized through a complex process of enzymatic reactions that occur in the Golgi apparatus in mammalian systems. Because there is currently no sequencer for glycans, technologies such as mass spectrometry is used to characterize glycans in a biological sample to ascertain its glycome. This is a tedious process that requires high levels of expertise and equipment. Thus, the enzymes that work on glycans, called glycogenes or glycoenzymes, have been studied to better understand glycan function. With the development of glycan-related databases and a glycan repository, bioinformatics approaches have attempted to predict the glycosylation pathway and the glycosylation sites on proteins. This chapter introduces these methods and related Web resources for understanding glycan function.
Keywords: Biosynthesis; Glycans; Glycobiology; Glycome; Glycosylation.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
Similar articles
-
In silico simulation of glycosylation and related pathways.Anal Bioanal Chem. 2024 Jul;416(16):3687-3696. doi: 10.1007/s00216-024-05331-8. Epub 2024 May 15. Anal Bioanal Chem. 2024. PMID: 38748247 Free PMC article. Review.
-
Plant protein glycosylation.Glycobiology. 2016 Sep;26(9):926-939. doi: 10.1093/glycob/cww023. Epub 2016 Feb 23. Glycobiology. 2016. PMID: 26911286 Free PMC article. Review.
-
Translation of genome to glycome: role of the Golgi apparatus.FEBS Lett. 2019 Sep;593(17):2390-2411. doi: 10.1002/1873-3468.13541. Epub 2019 Aug 8. FEBS Lett. 2019. PMID: 31330561 Review.
-
Systems analysis of N-glycan processing in mammalian cells.PLoS One. 2007 Aug 8;2(8):e713. doi: 10.1371/journal.pone.0000713. PLoS One. 2007. PMID: 17684559 Free PMC article.
-
Golgi linked protein glycosylation and associated diseases.Semin Cell Dev Biol. 2009 Sep;20(7):762-9. doi: 10.1016/j.semcdb.2009.03.004. Semin Cell Dev Biol. 2009. PMID: 19508859 Review.
Cited by
-
In silico simulation of glycosylation and related pathways.Anal Bioanal Chem. 2024 Jul;416(16):3687-3696. doi: 10.1007/s00216-024-05331-8. Epub 2024 May 15. Anal Bioanal Chem. 2024. PMID: 38748247 Free PMC article. Review.
References
-
- Kumozaki S, Sato K, Sakakibara Y (2015) A machine learning based approach to de novo sequencing of glycans from tandem mass spectrometry spectrum. Comput Biol Bioinformatics 12:1267–1274
MeSH terms
Substances
LinkOut - more resources
Full Text Sources