Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment
- PMID: 34779998
- DOI: 10.1007/s12011-021-03022-4
Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment
Abstract
Selenium, an essential trace element for human health, exerts an indispensable effect in maintaining physiological homeostasis and functions in the body. Selenium deficiency is associated with arthropathies, such as Kashin-Beck disease, rheumatoid arthritis, osteoarthritis, and osteoporosis. Selenium deficiency mainly affects the normal physiological state of bone and cartilage through oxidative stress reaction and immune reaction. This review aims to explore the role of selenium deficiency and its mechanisms existed in the pathogenesis of arthropathies. Meanwhile, this review also summarized various experiments to highlight the crucial functions of selenium in maintaining the homeostasis of bone and cartilage.
Keywords: Arthropathies; Kashin-Beck disease; Osteoarthritis; Osteoporosis; Rheumatoid arthritis; Selenium deficiency.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Similar articles
-
The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies.Exp Mol Med. 2020 Aug;52(8):1198-1208. doi: 10.1038/s12276-020-0408-y. Epub 2020 Aug 13. Exp Mol Med. 2020. PMID: 32788658 Free PMC article. Review.
-
Serious Selenium Deficiency in the Serum of Patients with Kashin-Beck Disease and the Effect of Nano-Selenium on Their Chondrocytes.Biol Trace Elem Res. 2020 Mar;194(1):96-104. doi: 10.1007/s12011-019-01759-7. Epub 2019 Jun 8. Biol Trace Elem Res. 2020. PMID: 31175635
-
Oxidant damage in Kashin-Beck disease and a rat Kashin-Beck disease model by employing T-2 toxin treatment under selenium deficient conditions.J Orthop Res. 2012 Aug;30(8):1229-37. doi: 10.1002/jor.22073. Epub 2012 Jan 31. J Orthop Res. 2012. PMID: 22294316
-
Expression and localization of the small proteoglycans decorin and biglycan in articular cartilage of Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency.Glycoconj J. 2019 Dec;36(6):451-459. doi: 10.1007/s10719-019-09889-9. Epub 2019 Sep 2. Glycoconj J. 2019. PMID: 31478096
-
Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium.Biol Trace Elem Res. 2017 Oct;179(2):178-184. doi: 10.1007/s12011-017-0964-8. Epub 2017 Feb 21. Biol Trace Elem Res. 2017. PMID: 28224461 Review.
Cited by
-
The beneficial and toxic effects of selenium on zebrafish. A systematic review of the literature.Toxicol Res (Camb). 2024 Apr 19;13(2):tfae062. doi: 10.1093/toxres/tfae062. eCollection 2024 Apr. Toxicol Res (Camb). 2024. PMID: 38645626 Review.
-
Selective Impact of Selenium Compounds on Two Cytokine Storm Players.J Pers Med. 2023 Sep 30;13(10):1455. doi: 10.3390/jpm13101455. J Pers Med. 2023. PMID: 37888066 Free PMC article.
-
A quantitative review of the effects of Se application on the reduction of Hg concentration in plant: a meta-analysis.Front Plant Sci. 2023 Jun 20;14:1199721. doi: 10.3389/fpls.2023.1199721. eCollection 2023. Front Plant Sci. 2023. PMID: 37409302 Free PMC article. Review.
-
Selenium-enriched plant foods: Selenium accumulation, speciation, and health functionality.Front Nutr. 2023 Feb 6;9:962312. doi: 10.3389/fnut.2022.962312. eCollection 2022. Front Nutr. 2023. PMID: 36815133 Free PMC article. Review.
-
Selenium Induces Pancreatic Cancer Cell Death Alone and in Combination with Gemcitabine.Biomedicines. 2022 Jan 11;10(1):149. doi: 10.3390/biomedicines10010149. Biomedicines. 2022. PMID: 35052828 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical