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Review
. 2022 Oct;200(10):4238-4249.
doi: 10.1007/s12011-021-03022-4. Epub 2021 Nov 15.

Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment

Huan Deng #  1 , Haobiao Liu #  1 , Zhihao Yang #  1 , Miaoye Bao  1 , Xue Lin  1 , Jing Han  2 , Chengjuan Qu  3
Affiliations
Review

Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment

Huan Deng et al. Biol Trace Elem Res. 2022 Oct.

Abstract

Selenium, an essential trace element for human health, exerts an indispensable effect in maintaining physiological homeostasis and functions in the body. Selenium deficiency is associated with arthropathies, such as Kashin-Beck disease, rheumatoid arthritis, osteoarthritis, and osteoporosis. Selenium deficiency mainly affects the normal physiological state of bone and cartilage through oxidative stress reaction and immune reaction. This review aims to explore the role of selenium deficiency and its mechanisms existed in the pathogenesis of arthropathies. Meanwhile, this review also summarized various experiments to highlight the crucial functions of selenium in maintaining the homeostasis of bone and cartilage.

Keywords: Arthropathies; Kashin-Beck disease; Osteoarthritis; Osteoporosis; Rheumatoid arthritis; Selenium deficiency.

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