Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI
- PMID: 34564301
- PMCID: PMC8482256
- DOI: 10.3390/tomography7030039
Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI
Abstract
Idiopathic pulmonary fibrosis, a pattern of interstitial lung disease, is often clinically unpredictable in its progression. This paper presents hyperpolarized Xenon-129 chemical shift imaging as a noninvasive, nonradioactive method of probing lung physiology as well as anatomy to monitor subtle changes in subjects with IPF. Twenty subjects, nine healthy and eleven IPF, underwent HP Xe-129 ventilation MRI and 3D-SBCSI. Spirometry was performed on all subjects before imaging, and DLCO and hematocrit were measured in IPF subjects after imaging. Images were post-processed in MATLAB and segmented using ANTs. IPF subjects exhibited, on average, higher Tissue/Gas ratios and lower RBC/Gas ratios compared with healthy subjects, and quantitative maps were more heterogeneous in IPF subjects. The higher ratios are likely due to fibrosis and thickening of the pulmonary interstitium. T2* relaxation was longer in IPF subjects and corresponded with hematocrit scores, although the mechanism is not well understood. A lower chemical shift in the red blood cell spectroscopic peak correlated well with a higher Tissue/RBC ratio and may be explained by reduced blood oxygenation. Tissue/RBC also correlated well, spatially, with areas of fibrosis in HRCT images. These results may help us understand the underlying mechanism behind gas exchange impairment and disease progression.
Keywords: MRI; hyperpolarized Xenon-129; idiopathic pulmonary fibrosis; interstitial lung disease.
Conflict of interest statement
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
Figures
Similar articles
-
Dissolved 129 Xe lung MRI with four-echo 3D radial spectroscopic imaging: Quantification of regional gas transfer in idiopathic pulmonary fibrosis.Magn Reson Med. 2021 May;85(5):2622-2633. doi: 10.1002/mrm.28609. Epub 2020 Nov 30. Magn Reson Med. 2021. PMID: 33252157
-
3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects.Tomography. 2022 Oct 13;8(5):2574-2587. doi: 10.3390/tomography8050215. Tomography. 2022. PMID: 36287814 Free PMC article.
-
Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis.Thorax. 2018 Jan;73(1):21-28. doi: 10.1136/thoraxjnl-2017-210070. Epub 2017 Aug 31. Thorax. 2018. PMID: 28860333 Free PMC article.
-
New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging.J Thorac Imaging. 2019 Mar;34(2):136-150. doi: 10.1097/RTI.0000000000000392. J Thorac Imaging. 2019. PMID: 30801449 Free PMC article. Review.
-
Hyperpolarized Gas MR Imaging: Technique and Applications.Magn Reson Imaging Clin N Am. 2015 May;23(2):217-29. doi: 10.1016/j.mric.2015.01.003. Magn Reson Imaging Clin N Am. 2015. PMID: 25952516 Free PMC article. Review.
Cited by
-
Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation.J Vis Exp. 2023 Nov 21;(201):10.3791/65982. doi: 10.3791/65982. J Vis Exp. 2023. PMID: 38078603 Free PMC article.
-
Simultaneous quantification of hyperpolarized xenon-129 ventilation and gas exchange with multi-breath xenon-polarization transfer contrast (XTC) MRI.Magn Reson Med. 2023 Dec;90(6):2334-2347. doi: 10.1002/mrm.29804. Epub 2023 Aug 3. Magn Reson Med. 2023. PMID: 37533368
-
Lung Volume Dependence and Repeatability of Hyperpolarized 129Xe MRI Gas Uptake Metrics in Healthy Volunteers and Participants with COPD.Radiol Cardiothorac Imaging. 2023 Jun 22;5(3):e220096. doi: 10.1148/ryct.220096. eCollection 2023 Jun. Radiol Cardiothorac Imaging. 2023. PMID: 37404786 Free PMC article.
-
Functional xenon-129 magnetic resonance imaging response to antifibrotic treatment in idiopathic pulmonary fibrosis.ERJ Open Res. 2023 Jun 26;9(3):00080-2023. doi: 10.1183/23120541.00080-2023. eCollection 2023 May. ERJ Open Res. 2023. PMID: 37377660 Free PMC article.
-
Hyperpolarized Xenon-129: A New Tool to Assess Pulmonary Physiology in Patients with Pulmonary Fibrosis.Biomedicines. 2023 May 25;11(6):1533. doi: 10.3390/biomedicines11061533. Biomedicines. 2023. PMID: 37371626 Free PMC article.
References
-
- Raghu G., Remy-Jardin M., Myers J.L., Richeldi L., Ryerson C.J., Lederer D.J., Behr J., Cottin V., Danoff S.K., Morell F., et al. Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. Am. J. Respir. Crit. Care Med. 2018;198:e44–e68. doi: 10.1164/rccm.201807-1255ST. - DOI - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous