Comment
doi: 10.1016/j.ccell.2021.01.014.
Epub 2021 Jan 28.
Subversion of calreticulin exposure as a strategy of immune escape
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- PMID: 33513346
- DOI: 10.1016/j.ccell.2021.01.014
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Subversion of calreticulin exposure as a strategy of immune escape
Cancer Cell.
.
Free article
Abstract
In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the "eat me" signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.
Copyright © 2021 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests G.K. and L.Z. are listed as inventors on several patents (WO2008028968A2, WO2011131472A1, WO2012007783A1) dealing with calreticulin and cancer immunosurveillance.
Comment on
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Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance.Cancer Cell. 2021 Apr 12;39(4):480-493.e6. doi: 10.1016/j.ccell.2020.12.023. Epub 2021 Jan 28. Cancer Cell. 2021. PMID: 33513345 Free PMC article.
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