An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2
- PMID: 3313052
- DOI: 10.1038/329840a0
An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2
Abstract
Recently the human T cell erythrocyte receptor CD2 has been shown to bind human erythrocytes through LFA-3, a heavily glycosylated surface protein of broad tissue distribution. CD2-LFA-3 interactions are important for cytolytic conjugate formation, for thymocyte adhesion, and for T cell activation. A complementary DNA clone encoding LFA-3 was isolated using a complementary DNA clone encoding LFA-3 was isolated using a novel transient expression system of mouse cells. The cDNA encodes a phospholipid-linked membrane protein whose extracellular domain shares significant homology with CD2. As CD2 is homologous with the neural cell adhesion molecule NCAM in immunoglobulin-like domains, cellular adhesion molecules in both neural and lymphoid tissues could have a common ancestor.
Similar articles
-
ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.Nature. 1988 Feb 18;331(6157):624-7. doi: 10.1038/331624a0. Nature. 1988. PMID: 3340213
-
Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA.J Immunol. 1995 Nov 15;155(10):4739-48. J Immunol. 1995. PMID: 7594475
-
The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression.Eur J Immunol. 1987 Jul;17(7):1015-20. doi: 10.1002/eji.1830170718. Eur J Immunol. 1987. PMID: 2440689
-
T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2.Semin Immunol. 1993 Aug;5(4):249-61. doi: 10.1006/smim.1993.1029. Semin Immunol. 1993. PMID: 7693022 Review.
-
The biology of CD2: adhesion, transmembrane signal, and regulatory receptor of immunity.J Surg Res. 1993 Mar;54(3):258-67. doi: 10.1006/jsre.1993.1041. J Surg Res. 1993. PMID: 8097269 Review.
Cited by
-
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity.Cancer Cell. 2023 Jul 10;41(7):1207-1221.e12. doi: 10.1016/j.ccell.2023.05.014. Epub 2023 Jun 15. Cancer Cell. 2023. PMID: 37327789 Free PMC article.
-
Protein Receptors Evolved from Homologous Cohesion Modules That Self-Associated and Are Encoded by Interactive Networked Genes.Life (Basel). 2021 Dec 3;11(12):1335. doi: 10.3390/life11121335. Life (Basel). 2021. PMID: 34947866 Free PMC article.
-
Upregulated CD58 is associated with clinicopathological characteristics and poor prognosis of patients with pancreatic ductal adenocarcinoma.Cancer Cell Int. 2021 Jun 30;21(1):327. doi: 10.1186/s12935-021-02037-0. Cancer Cell Int. 2021. PMID: 34193136 Free PMC article.
-
CD58 Immunobiology at a Glance.Front Immunol. 2021 Jun 8;12:705260. doi: 10.3389/fimmu.2021.705260. eCollection 2021. Front Immunol. 2021. PMID: 34168659 Free PMC article. Review.
-
A novel fluorescence-based biosynthetic trafficking method provides pharmacologic evidence that PI4-kinase IIIα is important for protein trafficking from the endoplasmic reticulum to the plasma membrane.BMC Cell Biol. 2015 Feb 27;16:5. doi: 10.1186/s12860-015-0049-5. BMC Cell Biol. 2015. PMID: 25886792 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
