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Review
. 2018 May 3:9:978.
doi: 10.3389/fimmu.2018.00978. eCollection 2018.

Targeting VEGF/VEGFR to Modulate Antitumor Immunity

Ju Yang  1 , Jing Yan  1 , Baorui Liu  1
Affiliations
Review

Targeting VEGF/VEGFR to Modulate Antitumor Immunity

Ju Yang et al. Front Immunol. .

Abstract

In addition to the crucial role in promoting the growth of tumor vessels, vascular endothelial growth factor (VEGF) is also immunosuppressive. VEGF can inhibit the function of T cells, increase the recruitment of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and hinder the differentiation and activation of dendritic cells (DCs). Recent studies have investigated the role of antiangiogenic agents in antitumor immunity, especially in recent 3 years. Therefore, it is necessary to update the role of targeting VEGF/VEGFR in antitumor immunity. In this review, we focus on the latest clinical and preclinical findings on the modulatory role of antiangiogenic agents targeting VEGF/VEGFR in immune cells, including effector T cells, Tregs, MDSCs, DCs, tumor-associated macrophages, and mast cells. Our review will be potentially helpful for the development of combinations of angiogenesis inhibitors with immunological modulators.

Keywords: T cells; angiogenesis; immune; tumor; vascular endothelial growth factor.

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Figures

Figure 1
Figure 1
Effects of vascular endothelial growth factor (VEGF) on T cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSC), and dendritic cell (DC).
See this image and copyright information in PMC

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References

    1. Chung AS, Ferrara N. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol (2011) 27:563–84.10.1146/annurev-cellbio-092910-154002 - DOI - PubMed
    1. Sia D, Alsinet C, Newell P, Villanueva A. VEGF signaling in cancer treatment. Curr Pharm Des (2014) 20:2834–42.10.2174/13816128113199990590 - DOI - PubMed
    1. Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer (2008) 8:604–17.10.1038/nrc2353 - DOI - PMC - PubMed
    1. Wang J, Chen J, Guo Y, Wang B, Chu H. Strategies targeting angiogenesis in advanced non-small cell lung cancer. Oncotarget (2017) 8:53854–72.10.18632/oncotarget.17957 - DOI - PMC - PubMed
    1. Simons M, Gordon E, Claesson-Welsh L. Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol (2016) 17:611–25.10.1038/nrm.2016.87 - DOI - PubMed

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