The Evolving Landscape of Brain Metastasis
- PMID: 29506669
- PMCID: PMC6602095
- DOI: 10.1016/j.trecan.2018.01.003
The Evolving Landscape of Brain Metastasis
Abstract
Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors.
Keywords: brain metastasis; genomics; microenvironment; neurocognition; prevention; therapy.
Copyright © 2018 Elsevier Inc. All rights reserved.
Figures
Similar articles
-
Radiation therapy and molecular-targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges.Pediatr Blood Cancer. 2021 May;68 Suppl 2:e28439. doi: 10.1002/pbc.28439. Epub 2020 Aug 22. Pediatr Blood Cancer. 2021. PMID: 32827353 Review.
-
Pediatric brain tumors: the era of molecular diagnostics, targeted and immune-based therapeutics, and a focus on long term neurologic sequelae.Curr Probl Cancer. 2021 Aug;45(4):100777. doi: 10.1016/j.currproblcancer.2021.100777. Epub 2021 Jul 16. Curr Probl Cancer. 2021. PMID: 34303558 Review.
-
Recent advances in managing brain metastasis.F1000Res. 2018 Nov 9;7:F1000 Faculty Rev-1772. doi: 10.12688/f1000research.15903.1. eCollection 2018. F1000Res. 2018. PMID: 30473769 Free PMC article. Review.
-
Advances in Experimental Targeted Therapy and Immunotherapy for Patients with Glioblastoma Multiforme.Anticancer Res. 2017 Jan;37(1):21-33. doi: 10.21873/anticanres.11285. Anticancer Res. 2017. PMID: 28011470 Review.
-
Toward precision immunotherapy using multiplex immunohistochemistry and in silico methods to define the tumor immune microenvironment.Cancer Immunol Immunother. 2021 Jul;70(7):1811-1820. doi: 10.1007/s00262-020-02801-7. Epub 2021 Jan 3. Cancer Immunol Immunother. 2021. PMID: 33389014 Free PMC article. Review.
Cited by
-
MicroRNAs in Lung Cancer Brain Metastasis.Int J Mol Sci. 2024 Sep 25;25(19):10325. doi: 10.3390/ijms251910325. Int J Mol Sci. 2024. PMID: 39408656 Free PMC article. Review.
-
Development of graded prognostic assessment for breast Cancer brain metastasis incorporating extracranial metastatic features: a retrospective analysis of 284 patients.BMC Cancer. 2024 Oct 10;24(1):1262. doi: 10.1186/s12885-024-12983-3. BMC Cancer. 2024. PMID: 39390441 Free PMC article.
-
Concise review: breast cancer stems cells and their role in metastases.Ann Med Surg (Lond). 2024 Jul 23;86(9):5266-5275. doi: 10.1097/MS9.0000000000002270. eCollection 2024 Sep. Ann Med Surg (Lond). 2024. PMID: 39238997 Free PMC article. Review.
-
Evolutionary Trend Analysis of Research on Immunotherapy for Brain Metastasis Based on Machine-Learning Scientometrics.Pharmaceuticals (Basel). 2024 Jun 28;17(7):850. doi: 10.3390/ph17070850. Pharmaceuticals (Basel). 2024. PMID: 39065701 Free PMC article.
-
Effect of different optimization parameters in single isocenter multiple brain metastases radiosurgery.Strahlenther Onkol. 2024 Sep;200(9):815-826. doi: 10.1007/s00066-024-02249-z. Epub 2024 Jul 8. Strahlenther Onkol. 2024. PMID: 38977432 Free PMC article.
References
-
- Bamholtz-Sloan JS et al. (2004) Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) to in the Metropolitan Detroit Cancer Surveillance System. J. Din. Oneal 22, 2865–2872 - PubMed
-
- Schouten LJ. et al. (2002) Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 94, 2698–2705 - PubMed
-
- Gállego Perez-Larraya J, and Hildebrand J (2014) Brain metastases. Handbook Clin. Neurol 121, 1143–1157 - PubMed
-
- Guérin A et al. (2016) The economic burden of brain metastasis among lung cancer patients in the United States. J. Med. Econ 19, 526–536 - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical