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Comment
. 2016 Feb 8;29(2):135-6.
doi: 10.1016/j.ccell.2016.01.011.

Defining the Molecular Alterations of Ampullary Carcinoma

Jing Tan  1 , Patrick Tan  2 , Bin Tean Teh  3
Affiliations
Free article
Comment

Defining the Molecular Alterations of Ampullary Carcinoma

Jing Tan et al. Cancer Cell. .
Free article

Abstract

Ampullary carcinomas represent a group of heterogeneous tumors that can be histologically divided into two subtypes with distinct pathogenic and clinical characteristics. Yachida et al. (2016) and Gingras et al. (2016) now report the genomic landscape of ampullary carcinoma, providing insights into molecular drivers with clinical implications for diagnosis and therapeutics.

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  • Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.
    Gingras MC, Covington KR, Chang DK, Donehower LA, Gill AJ, Ittmann MM, Creighton CJ, Johns AL, Shinbrot E, Dewal N, Fisher WE; Australian Pancreatic Cancer Genome Initiative; Pilarsky C, Grützmann R, Overman MJ, Jamieson NB, Van Buren G 2nd, Drummond J, Walker K, Hampton OA, Xi L, Muzny DM, Doddapaneni H, Lee SL, Bellair M, Hu J, Han Y, Dinh HH, Dahdouli M, Samra JS, Bailey P, Waddell N, Pearson JV, Harliwong I, Wang H, Aust D, Oien KA, Hruban RH, Hodges SE, McElhany A, Saengboonmee C, Duthie FR, Grimmond SM, Biankin AV, Wheeler DA, Gibbs RA. Gingras MC, et al. Cell Rep. 2016 Feb 2;14(4):907-919. doi: 10.1016/j.celrep.2015.12.005. Epub 2016 Jan 21. Cell Rep. 2016. PMID: 26804919 Free PMC article.
  • Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma.
    Yachida S, Wood LD, Suzuki M, Takai E, Totoki Y, Kato M, Luchini C, Arai Y, Nakamura H, Hama N, Elzawahry A, Hosoda F, Shirota T, Morimoto N, Hori K, Funazaki J, Tanaka H, Morizane C, Okusaka T, Nara S, Shimada K, Hiraoka N, Taniguchi H, Higuchi R, Oshima M, Okano K, Hirono S, Mizuma M, Arihiro K, Yamamoto M, Unno M, Yamaue H, Weiss MJ, Wolfgang CL, Furukawa T, Nakagama H, Vogelstein B, Kiyono T, Hruban RH, Shibata T. Yachida S, et al. Cancer Cell. 2016 Feb 8;29(2):229-40. doi: 10.1016/j.ccell.2015.12.012. Epub 2016 Jan 21. Cancer Cell. 2016. PMID: 26806338 Free PMC article.

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