Computational tools for epitope vaccine design and evaluation
- PMID: 25837467
- PMCID: PMC4456225
- DOI: 10.1016/j.coviro.2015.03.013
Computational tools for epitope vaccine design and evaluation
Abstract
Rational approaches will be required to develop universal vaccines for viral pathogens such as human immunodeficiency virus, hepatitis C virus, and influenza, for which empirical approaches have failed. The main objective of a rational vaccine strategy is to design novel immunogens that are capable of inducing long-term protective immunity. In practice, this requires structure-based engineering of the target neutralizing epitopes and a quantitative readout of vaccine-induced immune responses. Therefore, computational tools that can facilitate these two areas have played increasingly important roles in rational vaccine design in recent years. Here we review the computational techniques developed for protein structure prediction and antibody repertoire analysis, and demonstrate how they can be applied to the design and evaluation of epitope vaccines.
Copyright © 2015 Elsevier B.V. All rights reserved.
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References
-
-
Nabel GJ. Designing Tomorrow's Vaccines. New Engl J Med. 2013;368:551–560. • This review covered a wide range of topics in vaccine research, including past successes and current challenges, new conceptual and technological advances, clinical translation and implementation, and future vaccine development.
-
-
-
Kwong PD, Mascola JR, Nabel GJ. Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning. Nat Rev Immunol. 2013;13:693–701. • The authors discussed the role of broadly neutralizing antibodies in structural analysis of antibody-epitope interactions and rational design of immunogens to target the intermediate antibodies during B-cell development.
-
-
-
Walker LM, Burton DR. Rational antibody-based HIV-1 vaccine design: current approaches and future directions. Curr Opin Immunol. 2010;22:358–366. •• This was one of the earliest articles describing the concept and major components of an antibody-based rational vaccine design approach. The importance of broadly neutralizing antibody identification was highlighted in the review.
-
-
-
Haynes BF, Kelsoe G, Harrison SC, Kepler TB. B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol. 2012;30:423–433. •• The authors extended the rational vaccine approach of Walker
et al. by including the intermediate antibodies derived from a neutralizing B-cell lineage as templates to design a series of immunogens to guide the B-cell development during the vaccination.
-
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