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Review
. 2014 Aug 1;588(15):2537-44.
doi: 10.1016/j.febslet.2014.05.003. Epub 2014 May 17.

Synthetic therapeutic gene circuits in mammalian cells

Haifeng Ye  1 , Martin Fussenegger  2
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Free article
Review

Synthetic therapeutic gene circuits in mammalian cells

Haifeng Ye et al. FEBS Lett. .
Free article

Abstract

In the emerging field of synthetic biology, scientists are focusing on designing and creating functional devices, systems, and organisms with novel functions by engineering and assembling standardised biological building blocks. The progress of synthetic biology has significantly advanced the design of functional gene networks that can reprogram metabolic activities in mammalian cells and provide new therapeutic opportunities for future gene- and cell-based therapies. In this review, we describe the most recent advances in synthetic mammalian gene networks designed for biomedical applications, including how these synthetic therapeutic gene circuits can be assembled to control signalling networks and applied to treat metabolic disorders, cancer, and immune diseases. We conclude by discussing the various challenges and future prospects of using synthetic mammalian gene networks for disease therapy.

Keywords: Cell therapy; Gene circuits; Gene regulation; Gene therapy; Synthetic biology.

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