Angiogenesis and vasculogenesis in rheumatoid arthritis
- PMID: 20305562
- DOI: 10.1097/BOR.0b013e328337c95a
Angiogenesis and vasculogenesis in rheumatoid arthritis
Abstract
Purpose of review: Angiogenesis is the formation of new capillaries from pre-existing vessels, whereas vasculogenesis is de-novo capillary formation from endothelial precursor cells (EPCs). Current understanding of the role of angiogenesis and vasculogenesis in rheumatoid arthritis (RA) and possibilities of therapeutic intervention should be summarized.
Recent findings: There have been many recent studies on the role of the hypoxia and hypoxia-inducible factor (HIF)-vascular endothelial growth factor (VEGF)-angiopoietin axis in angiogenesis associated with RA. The role of additional growth factors, chemokines, cytokines, matrix components and adhesion molecules has been further characterized. Macrophage migration inhibitory factor (MIF) may link inflammation, angiogenesis and atherosclerosis. Junctional adhesion molecules (JAMs) and focal adhesion kinases (FAKs) have recently been implicated in inflammatory angiogenesis. Novel information regarding the role of serum amyloid A (SAA) and sphingosine kinase has become available. Most of these angiogenic factors have recently been targeted using various techniques and arthritis models. Whereas angiogenesis is abundant in RA, there is defective EPC function and vasculogenesis leading to atherosclerosis and vascular disease in arthritis. Treatment with EPCs already under investigation in vascular diseases may also be attempted in RA.
Summary: Targeting angiogenesis and restoration of vasculogenesis may be beneficial for the therapy and outcome of RA.
Similar articles
-
New insights in synovial angiogenesis.Joint Bone Spine. 2010 Jan;77(1):13-9. doi: 10.1016/j.jbspin.2009.05.011. Epub 2009 Dec 21. Joint Bone Spine. 2010. PMID: 20022538 Free PMC article. Review.
-
Angiogenesis in rheumatoid arthritis.Autoimmunity. 2009 Nov;42(7):563-73. doi: 10.1080/08916930903143083. Autoimmunity. 2009. PMID: 19863375 Free PMC article. Review.
-
The potential role of angiogenic factors in rheumatoid arthritis.Int J Rheum Dis. 2014 May;17(4):369-83. doi: 10.1111/1756-185X.12280. Epub 2014 Jan 28. Int J Rheum Dis. 2014. PMID: 24467605 Review.
-
Disease modifying and antiangiogenic activity of 2-methoxyestradiol in a murine model of rheumatoid arthritis.BMC Musculoskelet Disord. 2009 May 1;10:46. doi: 10.1186/1471-2474-10-46. BMC Musculoskelet Disord. 2009. PMID: 19409094 Free PMC article.
-
Vasculogenesis in rheumatoid arthritis.Arthritis Res Ther. 2010;12(2):110. doi: 10.1186/ar2943. Epub 2010 Mar 18. Arthritis Res Ther. 2010. PMID: 20346090 Free PMC article.
Cited by
-
Angioembolization in the management of joint pain: current concepts.Orthopadie (Heidelb). 2024 Sep;53(9):688-697. doi: 10.1007/s00132-024-04531-5. Epub 2024 Jul 26. Orthopadie (Heidelb). 2024. PMID: 39060549 Review. English.
-
Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides.Molecules. 2023 Mar 8;28(6):2483. doi: 10.3390/molecules28062483. Molecules. 2023. PMID: 36985456 Free PMC article. Review.
-
Screening and Analysis of Potential Critical Gene in Acute Myocardial Infarction Based on a miRNA-mRNA Regulatory Network.Int J Gen Med. 2022 Mar 10;15:2847-2860. doi: 10.2147/IJGM.S354641. eCollection 2022. Int J Gen Med. 2022. PMID: 35300139 Free PMC article.
-
Fractal analysis of perfusion imaging in synovitis: a novel imaging biomarker for grading inflammatory activity based on assessing angiogenesis.RMD Open. 2022 Feb;8(1):e002078. doi: 10.1136/rmdopen-2021-002078. RMD Open. 2022. PMID: 35149603 Free PMC article.
-
Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment.Biol Trace Elem Res. 2022 Oct;200(10):4238-4249. doi: 10.1007/s12011-021-03022-4. Epub 2021 Nov 15. Biol Trace Elem Res. 2022. PMID: 34779998 Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous