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Practice Guideline
. 2009 Apr;49(4):1335-74.
doi: 10.1002/hep.22759.

Diagnosis, management, and treatment of hepatitis C: an update

Marc G Ghany  1 , Doris B Strader, David L Thomas, Leonard B Seeff; American Association for the Study of Liver Diseases
Collaborators, Affiliations
Practice Guideline

Diagnosis, management, and treatment of hepatitis C: an update

Marc G Ghany et al. Hepatology. 2009 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Graphic display of virological responses. RVR, rapid virological response (clearance of HCV from serum by week 4 using a sensitive PCR-based assay); EVR, early virological response (≥2 log reduction in HCV RNA level compared to baseline HCV RNA level or HCV RNA negative at treatment week 12); SVR, sustained virological response (HCV RNA negative 24 weeks after cessation of treatment); relapse, reappearance of HCV RNA in serum after therapy is discontinued; nonresponder, failure to clear HCV RNA from serum after 24 weeks of therapy; partial nonresponder, 2 log decrease in HCV RNA but still HCV RNA positive at week 24; null nonresponder, failure to decrease HCV RNA by < 2 logs after 24 week of therapy.
Figure 2
Figure 2
Virological responses to pegylated interferon and ribavirin in the two U.S. Registration trials., ETR, end-of-treatment response; SVR, sustained virological response.
Figure 3
Figure 3
Treatment algorithm for managing and treating patients with chronic HCV infection, genotype 1. SVR, sustained virologic response; EVR, early virologic response. RVR is omitted from this treatment algorithm because it has not yet been adequately evaluated. HCV RNA should be quantitated using a sensitive assay (10–50 IU/mL).
Figure 4
Figure 4
Treatment algorithm for managing and treating patients with chronic HCV infection, genotype 2 or 3. EVR, early virologic response; ETR, end of treatment response; SVR, sustained virologic response. RVR is omitted from this treatment algorithm because it has not yet been adequately evaluated. HCV RNA should be quantitated using a sensitive assay (10–50 IU/mL).
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