Review
doi: 10.1038/nri2366.
New roles for TIM family members in immune regulation
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- PMID: 18617884
- DOI: 10.1038/nri2366
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Review
New roles for TIM family members in immune regulation
Nat Rev Immunol.
2008 Aug.
Abstract
Members of the TIM (T-cell immunoglobulin domain and mucin domain) protein family are emerging as important regulators of immune responses. As their names imply, the TIM proteins were originally thought to be T-cell-specific molecules that served mainly to regulate T-helper-cell responses. However, the recent discovery that antigen-presenting cells also express TIM molecules and the identification of new TIM-protein ligands has expanded the known roles of the TIM proteins in immune regulation.
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