Comment
doi: 10.1126/science.290.5494.1170.
NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation
Affiliations
- PMID: 11073458
- DOI: 10.1126/science.290.5494.1170
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Comment
NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation
Science.
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Erratum in
- Science 2001 Mar 9;291(5510):1902
Abstract
The hippocampal CA1 region is crucial for converting new memories into long-term memories, a process believed to continue for week(s) after initial learning. By developing an inducible, reversible, and CA1-specific knockout technique, we could switch N-methyl-D-aspartate (NMDA) receptor function off or on in CA1 during the consolidation period. Our data indicate that memory consolidation depends on the reactivation of the NMDA receptor, possibly to reinforce site-specific synaptic modifications to consolidate memory traces. Such a synaptic reinforcement process may also serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage.
Comment on
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Memory consolidation and NMDA receptors: discrepancy between genetic and pharmacological approaches.Science. 2001 Aug 3;293(5531):755. doi: 10.1126/science.293.5531.755a. Science. 2001. PMID: 11486056 No abstract available.
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