A lesion was the abnormal damage of tissue caused by illness or violence.
The Akaali suffering from a serious disease, a poisoning due to the intoxicated water supplies with tetracyanate 622, were identified by mottled skin and lesions on their faces. (ENT: "Civilization")
In 2153, a Vulcan crewmember of the Seleya caused a bloody lesion on Captain Jonathan Archer's left cheek while attacking him in a corridor. (ENT: "Impulse")
The Aldean sculptor Leda suffered from lesions on her skin due to radiation poisoning but the Aldean medicine was able to cure her. (TNG: "When The Bough Breaks")
Several crewmembers of the USS Voyager suffered from lesions following the transport of the ship into the Delta Quadrant. (VOY: "Caretaker")
The Vhnori Ptera died of a tumorous lesion to her midbrain. (VOY: "Emanations")