(Q86701386)

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Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model

scientific article published on 02 May 2013

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23636640%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23636640%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

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Europe PubMed Central

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29 February 2020

author name string

B A Omar

1

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29 February 2020

M S Winzell

3

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Europe PubMed Central

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29 February 2020

U Voss

4

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Europe PubMed Central

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29 February 2020

E Ekblad

5

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29 February 2020

J E Foley

6

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29 February 2020

B Ahrén

7

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29 February 2020

publication date

2 May 2013

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29 February 2020

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Europe PubMed Central

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29 February 2020

56

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29 February 2020

8

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Europe PubMed Central

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29 February 2020

1752-1760

1 reference

Europe PubMed Central

PubMed publication ID

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29 February 2020

Animal models of spontaneous autoimmune disease: type 1 diabetes in the nonobese diabetic mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination therapy with nateglinide and vildagliptin improves postprandial metabolic derangements in Zucker fatty rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of new-onset diabetes through modulating inflammation and stimulating beta-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NOD mice and autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased β-cell volume in mice fed a high-fat diet: a dynamic study over 12 months

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta cells are important for islet innervation: evidence from purified rat islet-cell grafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between beta-cell mass and fasting blood glucose concentration in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidants, oxidative stress and the biology of ageing

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptive beta-cell proliferation is severely restricted with advanced age.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic administration of DSP-7238, a novel, potent, specific and substrate-selective DPP IV inhibitor, improves glycaemic control and beta-cell damage in diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose regulation of β‐cell stress in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 diabetes care: the role of insulin-sensitizing agents and practical implications for cardiovascular disease prevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The DPP-4 inhibitor vildagliptin increases pancreatic beta cell mass in neonatal rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The future of incretin-based therapy: novel avenues--novel targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure and function of CD26 in the T-cell immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The islet enhancer vildagliptin: mechanisms of improved glucose metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutritional models of type 2 diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of chronic administration of alogliptin on the development of diabetes and β-cell function in high fat diet/streptozotocin diabetic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in age at diagnosis of type 2 diabetes mellitus in the United States, 1988 to 2000.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/23636640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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