(Q51061315)

28 March 2018

title

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment. (English)

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Emma Jones

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28 March 2018

author name string

Leung RK

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Thomson K

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Van den Broek M

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Sierro S

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Alsheikhly AR

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McMichael A

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Rahemtulla A

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language of work or name

English

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publication date

1 December 2001

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28 March 2018

published in

Nature Immunology

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28 March 2018

volume

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issue

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page(s)

1167-1173

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28 March 2018

Molecular components of T-cell recognition

cites work

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Selective events in T cell development

21 January 2018

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Positive selection of thymocytes bearing alpha beta T cell receptors.

21 January 2018

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Lymphocyte lineage commitment: instruction versus selection

21 January 2018

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Thymocyte lineage commitment: is it instructed or stochastic?

21 January 2018

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A challenge to the instructive model of positive selection

21 January 2018

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Another view of the selective model of thymocyte selection.

21 January 2018

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Development of mature CD8+ thymocytes: selection rather than instruction?

21 January 2018

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Stochastic component to development of class I major histocompatibility complex-specific T cells

21 January 2018

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Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice

21 January 2018

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A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice.

21 January 2018

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Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity.

21 January 2018

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The selection of the α,β heterodimeric T-cell receptor for antigen

21 January 2018

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Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

21 January 2018

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Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

21 January 2018

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Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages

21 January 2018

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Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

21 January 2018

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Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

21 January 2018

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Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

21 January 2018

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CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection.

21 January 2018

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The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

21 January 2018

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Lck activity controls CD4/CD8 T cell lineage commitment.

21 January 2018

1 reference

Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites

21 January 2018

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A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

21 January 2018

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Characterization of a promoter within the first intron of the human CD4 gene

21 January 2018

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Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells

21 January 2018

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Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system

21 January 2018

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Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

21 January 2018

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Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

21 January 2018

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7 January 2021

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

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7 January 2021

A transcriptional silencer controls the developmental expression of the CD4 gene.

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7 January 2021

Multiple negative and positive cis-acting elements control the expression of the murine CD4 gene

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7 January 2021

Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

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7 January 2021

Identifiers

DOI

10.1038/NI733

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28 March 2018

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28 March 2018