(Q47137924)

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Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

scientific article published on 31 August 2017

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28 March 2020

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs (English)

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28 March 2020

12

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28 March 2020

16

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28 March 2020

1

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28 March 2020

2

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28 March 2020

Alberto Massarotti

4

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28 March 2020

Carlo Cosimo Campa

10

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28 March 2020

Gian Cesare Tron

17

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28 March 2020

author name string

Silvio Aprile

3

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28 March 2020

Alex Berndt

5

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28 March 2020

Alessia Griglio

6

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28 March 2020

Marta Serafini

7

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28 March 2020

Valentina Mercalli

8

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28 March 2020

Clarissa Landoni

9

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28 March 2020

Jean Piero Margaria

11

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28 March 2020

Giorgio Grosa

13

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28 March 2020

Giovanni Sorba

14

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28 March 2020

Roger Williams

15

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28 March 2020

publication date

31 August 2017

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28 March 2020

1 reference

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28 March 2020

12

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28 March 2020

18

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28 March 2020

1542-1554

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28 March 2020

Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents

1 reference

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23 May 2018

PI3K isoform-selective inhibitors: next-generation targeted cancer therapies

1 reference

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23 May 2018

Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries

1 reference

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23 May 2018

Class I PI 3-kinases: Function and evolution

1 reference

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23 May 2018

PI3K inhibitors in inflammation, autoimmunity and cancer.

1 reference

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23 May 2018

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).

1 reference

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23 May 2018

Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma

1 reference

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23 May 2018

Selective and potent small-molecule inhibitors of PI3Ks

1 reference

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23 May 2018

Methods to measure the enzymatic activity of PI3Ks

1 reference

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23 May 2018

The chemical biology of phosphoinositide 3-kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5697638

23 May 2018

Synthesis and characterization of a novel prostate cancer-targeted phosphatidylinositol-3-kinase inhibitor prodrug

1 reference

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23 May 2018

Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy.

1 reference

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23 May 2018

Click chemistry: 1,2,3-triazoles as pharmacophores

1 reference

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23 May 2018

Present and future of PI3K pathway inhibition in cancer: perspectives and limitations

1 reference

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23 May 2018

PI3K: from the bench to the clinic and back

1 reference

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23 May 2018

Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

1 reference

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23 May 2018

Novel inhibitors of the PI3K family

1 reference

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23 May 2018

Click chemistry and medicinal chemistry: a case of "cyclo-addiction".

1 reference

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23 May 2018

A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

1 reference

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23 May 2018

Targeting phosphoinositide 3-kinase: moving towards therapy

1 reference

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23 May 2018

Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes.

1 reference

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23 May 2018

Polytriazoles as copper(I)-stabilizing ligands in catalysis

1 reference

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23 May 2018

The growing impact of click chemistry on drug discovery

1 reference

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23 May 2018

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

1 reference

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23 May 2018

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

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23 May 2018

Signaling by distinct classes of phosphoinositide 3-kinases

1 reference

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23 May 2018

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

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23 May 2018

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1 reference

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23 May 2018

Potent inhibitors of phosphatidylinositol 3 (PI3) kinase that have antiproliferative activity only when delivered as prodrug forms.

1 reference

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15 August 2018

Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors

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15 August 2018

Role of PI3K/Akt signaling in insulin-like growth factor-1 (IGF-1) skin tumor promotion

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15 August 2018

CuI-Catalyzed Alkyne-Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

1 reference

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The biochemistry of drug metabolism--an introduction: part 3. Reactions of hydrolysis and their enzymes

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Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?

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Identifiers

10.1002/CMDC.201700340

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28 March 2020

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28 March 2020

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28 March 2020

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