(Q43941701)

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The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

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Europe PubMed Central

PubMed publication ID

28 November 2017

The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

protein ubiquitination

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based on heuristic

inferred from title

author name string

Harumi Shimizu

1

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Lindsay R Burch

2

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Amanda J Smith

3

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

David Dornan

4

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Maura Wallace

5

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Kathryn L Ball

6

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Ted R Hupp

7

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

language of work or name

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publication date

29 March 2002

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Europe PubMed Central

PubMed publication ID

28 November 2017

number of pages

13

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

28 November 2017

277

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Europe PubMed Central

PubMed publication ID

28 November 2017

32

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

28446-28458

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Regulation of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

New approaches to understanding p53 gene tumor mutation spectra

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Nine hydrophobic side chains are key determinants of the thermodynamic stability and oligomerization status of tumour suppressor p53 tetramerization domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Allosteric activation of latent p53 tetramers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Regulation of p53 function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Regulation of mutant p53 temperature-sensitive DNA binding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Covalent and noncovalent modifiers of the p53 protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Repression of p53-mediated transcription by MDM2: a dual mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Mdm2 association with p53 targets its ubiquitination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Defect in the p53-Mdm2 autoregulatory loop resulting from inactivation of TAF(II)250 in cell cycle mutant tsBN462 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Modification of an N-terminal regulatory domain of T antigen restores p53-T antigen complex formation in the absence of an essential metal ion cofactor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Two cellular proteins that bind to wild-type but not mutant p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Apoptotic and growth-promoting activity of E2F modulated by MDM2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

A Role for the Polyproline Domain of p53 in Its Regulation by Mdm2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Mechanism of folding and assembly of a small tetrameric protein domain from tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Strategies for manipulating the p53 pathway in the treatment of human cancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Caspase-3-dependent and -independent degradation of 28 S ribosomal RNA may be involved in the inhibition of protein synthesis during apoptosis initiated by death receptor engagement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Molecular evolution of the thermosensitive PAb1620 epitope of human p53 by DNA shuffling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202296200

21 January 2018

Identifiers

10.1074/JBC.M202296200

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

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