(Q43652223)

25 November 2017

title

Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants (English)

1 reference

25 November 2017

Inga A

1 reference

25 November 2017

Resnick MA

series ordinal

1 reference

25 November 2017

language of work or name

English

0 references

publication date

1 June 2001

1 reference

25 November 2017

1 reference

25 November 2017

1 reference

25 November 2017

1 reference

25 November 2017

page(s)

3409-3419

1 reference

Regulation of p53 stability

25 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Suppression of human colorectal carcinoma cell growth by wild-type p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Human p53 inhibits growth in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Dominant-negative p53 mutations selected in yeast hit cancer hot spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Regulation of p53 downstream genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

A simple p53 functional assay for screening cell lines, blood, and tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Use of transcription reporters with novel p53 binding sites to target tumour cells expressing endogenous or virally transduced p53 mutants with altered sequence-specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

p53-oriented cancer therapies: current progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Oncogenic forms of p53 inhibit p53-regulated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

21 January 2018

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

How p53 binds DNA as a tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Regulation of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Increased apoptosis induction by 121F mutant p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Mammalian p53 can function as a transcription factor in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Structural aspects of the p53 protein in relation to gene evolution: a second look.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Discrimination of DNA Binding Sites by Mutant p53 Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

Prognostic significance ofp53 mutation in breast cancer: Frequent detection of non-missense mutations by yeast functional assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

BTG gene expression in the p53-dependent and -independent cellular response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

Mutation of conserved domain II alters the sequence specificity of DNA binding by the p53 protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

Determining mutational fingerprints at the human p53 locus with a yeast functional assay: a new tool for molecular epidemiology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

PCR-based random mutagenesis using manganese and reduced dNTP concentration.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

New developments in the multi-site phosphorylation and integration of stress signalling at p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

High frequency in esophageal cancers of p53 alterations inactivating the regulation of genes involved in cell cycle and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

Structure-based rescue of common tumor-derived p53 mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204457

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204457

1 reference

Dimensions Publication ID

25 November 2017

1037531092

0 references

1 reference