(Q42526729)

1 November 2017

title

Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. (English)

1 reference

1 November 2017

James R Jabbur

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1 November 2017

Amy D Tabor

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1 November 2017

Xiaodong Cheng

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1 November 2017

Hua Wang

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1 November 2017

Motonari Uesugi

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1 November 2017

Guillermina Lozano

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1 November 2017

Wei Zhang

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1 November 2017

language of work or name

English

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publication date

1 October 2002

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1 November 2017

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1 November 2017

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1 November 2017

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1 November 2017

page(s)

7100-7113

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Recruitment of p300/CBP in p53-dependent signal pathways

1 November 2017

cites work

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

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Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

21 January 2018

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

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Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation

21 January 2018

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Divergent hTAFII31-binding motifs hidden in activation domains

21 January 2018

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Cellular responses to ionizing radiation: effects of interrupting DNA repair with chemical agents

21 January 2018

1 reference

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Regulation of p53 downstream genes.

21 January 2018

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Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Identification of a sequence element from p53 that signals for Mdm2-targeted degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Synergistic activation of transcription by CBP and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Protein modelling for all

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

p53 Antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Regulation of Mdm2-directed degradation by the C terminus of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Functional analysis and intracellular localization of p53 modified by SUMO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Wild-type p53 binds to the TATA-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Induced alpha helix in the VP16 activation domain upon binding to a human TAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

GADD45 induction of a G2/M cell cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Comparative study of the p53-mdm2 and p53-MDMX interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205856

1 reference

Dimensions Publication ID

1 November 2017

1053467781

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1 reference