(Q40745449)

23 September 2017

title

Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase (English)

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23 September 2017

Toshifumi Fukuda

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23 September 2017

Kazutoshi Kiuchi

series ordinal

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23 September 2017

Masahide Takahashi

series ordinal

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23 September 2017

language of work or name

English

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publication date

8 March 2002

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

277

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23 September 2017

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23 September 2017

page(s)

19114-19121

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The GDNF/RET signaling pathway and human diseases

23 September 2017

cites work

1 reference

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Renal and neuronal abnormalities in mice lacking GDNF

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Defects in enteric innervation and kidney development in mice lacking GDNF

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Renal agenesis and the absence of enteric neurons in mice lacking GDNF

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The Ret Receptor Protein Tyrosine Kinase Associates with the SH2-containing Adapter Protein Grb10

21 January 2018

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A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

21 January 2018

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The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma

21 January 2018

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Identification of Shc docking site on Ret tyrosine kinase

21 January 2018

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21 January 2018

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Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.

21 January 2018

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Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation

21 January 2018

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Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

21 January 2018

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Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

21 January 2018

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The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.

21 January 2018

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21 January 2018

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Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

21 January 2018

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Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.

21 January 2018

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Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation

21 January 2018

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Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation

21 January 2018

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21 January 2018

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21 January 2018

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RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho.

21 January 2018

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21 January 2018

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Growth cone guidance: first steps towards a deeper understanding

21 January 2018

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Rho GTPases in neuronal morphogenesis

21 January 2018

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Rho GTPases in growth cone guidance

21 January 2018

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Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways

21 January 2018

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21 January 2018

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Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins

21 January 2018

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Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4, 5-bisphosphate.

21 January 2018

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Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities

21 January 2018

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Regulatory mechanisms that modulate signalling by G-protein-coupled receptors

21 January 2018

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Regulation of adenylyl cyclase in the central nervous system.

21 January 2018

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Protein kinase A anchoring

21 January 2018

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cAMP signaling in neurons: patterns of neuronal expression and intracellular localization for a novel protein, AKAP 150, that anchors the regulatory subunit of cAMP-dependent protein kinase II beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200643200

Signaling from Ras to Rac and beyond: not just a matter of GEFs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200643200

Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation

21 January 2018

1 reference

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EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M200643200

1 reference

23 September 2017

1 reference