(Q37881804)

24 August 2017

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title

Rho-kinase: important new therapeutic target in cardiovascular diseases (English)

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24 August 2017

main subject

cardiovascular disease

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Kimio Satoh

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24 August 2017

Yoshihiro Fukumoto

series ordinal

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24 August 2017

Hiroaki Shimokawa

series ordinal

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24 August 2017

publication date

27 May 2011

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American Journal of Physiology Heart and Circulatory Physiology

24 August 2017

published in

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24 August 2017

volume

301

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24 August 2017

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24 August 2017

page(s)

H287-96

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Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

NADPH oxidase signaling and cardiac myocyte function.

21 January 2018

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Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: a new perspective

21 January 2018

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Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Vascular smooth muscle growth: autocrine growth mechanisms

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Preferential chemotaxis of activated human CD4+ T cells by extracellular cyclophilin A

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Angiotensin II-mediated development of vascular diseases

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho GTPases in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Oxidative stress and cardiovascular injury: Part II: animal and human studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho GTPases and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Long-Term Treatment With a Specific Rho-Kinase Inhibitor Suppresses Cardiac Allograft Vasculopathy in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Molecular basis of restenosis and novel issues of drug-eluting stents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A is a proinflammatory cytokine that activates endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Evidence for Protein Kinase C-Mediated Activation of Rho- Kinase in a Porcine Model of Coronary Artery Spasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A may contribute to the inflammatory processes in rheumatoid arthritis through induction of matrix degrading enzymes and inflammatory cytokines from macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Inhibitory effects of ML-9, wortmannin, and Y-27632 on the chemotaxis of vascular smooth muscle cells in response to platelet-derived growth factor-BB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho kinase (ROCK) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Inflammation in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Inflammation in atherosclerosis: transition from theory to practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho kinases in cardiovascular physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

The role of Rho protein signaling in hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Long-Term Inhibition of Rho-Kinase Suppresses Neointimal Formation After Stent Implantation in Porcine Coronary Arteries: Involvement of Multiple Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

New roles of myosin II during vesicle transport and fusion in chromaffin cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho and Rho kinase are involved in parathyroid hormone-stimulated protein kinase C alpha translocation and IL-6 promoter activity in osteoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

RhoE binds to ROCK I and inhibits downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rocks: multifunctional kinases in cell behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Atherosclerosis is an inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Antiischemic properties of fasudil in experimental models of vasospastic angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A - Promising New Target in Cardiovascular Therapy -

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

P2Y(1), P2Y(2), P2Y(4), and P2Y(6) receptors are coupled to Rho and Rho kinase activation in vascular myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Adiponectin and cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Primary endothelial dysfunction: atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Development of Rho-kinase inhibitors for cardiovascular medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho-kinase is an important therapeutic target in cardiovascular medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Small GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Role of oxidative stress in cardiac hypertrophy and remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Reactive oxygen species in the vasculature: molecular and cellular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Endothelium-derived free radicals: for worse and for better

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Ca2+ signaling in hypoxic pulmonary vasoconstriction: effects of myosin light chain and Rho kinase antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Contribution of cyclophilin A to the regulation of inflammatory processes in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Understanding abdominal aortic aneurysm

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Cyclophilin A up-regulates MMP-9 expression and adhesion of monocytes/macrophages via CD147 signalling pathway in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00327.2011

10.1152/AJPHEART.00327.2011

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference