(Q37801027)

23 August 2017

title

Anti-angiogenic effects of dietary isothiocyanates: mechanisms of action and implications for human health (English)

1 reference

23 August 2017

Anti-angiogenic effects of dietary isothiocyanates: Mechanisms of action and implications for human health (English)

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

4 August 2024

main subject

angiogenesis inhibitor

1 reference

based on heuristic

inferred from title

author

Sharifah S. Syed Alwi

object named as

Sharifah S. Syed Alwi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20955689

4 August 2024

Graham Packham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20955689

4 August 2024

Alison Donlevy

1 reference

23 August 2017

Breeze E. Cavell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20955689

4 August 2024

language of work or name

English

0 references

publication date

16 October 2010

1 reference

full work available at URL

23 August 2017

https://hal.archives-ouvertes.fr/hal-00654981/file/PEER_stage2_10.1016%252Fj.bcp.2010.10.005.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20955689

https://api.elsevier.com/content/article/PII:S0006295210007616?httpAccept=text/xml

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

https://api.elsevier.com/content/article/PII:S0006295210007616?httpAccept=text/plain

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

4 August 2024

published in

Biochemical Pharmacology

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23 August 2017

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23 August 2017

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23 August 2017

page(s)

327-336

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Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.

23 August 2017

cites work

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1158/0008-5472.CAN-08-1902

Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Molecular basis for chemoprevention by sulforaphane: a comprehensive review.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Multi-targeted prevention of cancer by sulforaphane

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Studies on the metabolism and excretion of benzyl isothiocyanate in man

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Dietary intake of Cruciferous vegetables, Glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Molecular mechanisms of Nrf2-mediated antioxidant response

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Dietary cancer chemopreventive agents - targeting inflammation and Nrf2 signaling pathway

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Angiogenesis as a biomarker and target in cancer chemoprevention

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

The angiogenic switch in carcinogenesis

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Inhibition of endothelial cell differentiation and proinflammatory cytokine production during angiogenesis by allyl isothiocyanate and phenyl isothiocyanate

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Cellular signal transduction of the hypoxia response

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Targeting the molecular basis for tumour hypoxia.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Regulation of translation initiation factors by signal transduction

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

eIF4E expression in tumors: its possible role in progression of malignancies

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Hypoxia inducible factor-1 independent pathways in tumor angiogenesis.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Cysteine-179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

AP-1 subunits: quarrel and harmony among siblings

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

AP-1 in mouse development and tumorigenesis

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Phenethyl isothiocyanate induces cell cycle arrest and reduction of alpha- and beta-tubulin isotypes in human prostate cancer cells

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Dietary agents as histone deacetylase inhibitors

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Targeting tumor angiogenesis with histone deacetylase inhibitors

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography–tandem mass spectrometry

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Quantitative measurement of sulforaphane, iberin and their mercapturic acid pathway metabolites in human plasma and urine using liquid chromatography–tandem electrospray ionisation mass spectrometry

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Decrease of plasma and urinary oxidative metabolites of acetaminophen after consumption of watercress by human volunteers

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Inactivation of cytochrome P450 2E1 by benzyl isothiocyanate

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Inhibition of rat liver cytochrome P450 isozymes by isothiocyanates and their conjugates: a structure-activity relationship study

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Effect of phenethyl isothiocyanate on microsomal N-nitrosodimethylamine metabolism and other monooxygenase activities

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cells

4 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Antimetastatic activity of Sulforaphane

4 August 2024

100

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA.

4 August 2024

101

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells

4 August 2024

102

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.10.005

4 August 2024

Identifiers

1 reference

23 August 2017

1 reference