(Q37800359)

23 August 2017

title

The importance of natural IgM: scavenger, protector and regulator (English)

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23 August 2017

Michael R Ehrenstein

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Clare A Notley

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23 August 2017

publication date

15 October 2010

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Nature Reviews Immunology

23 August 2017

published in

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23 August 2017

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23 August 2017

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23 August 2017

page(s)

778-786

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B1 Cells Contribute to Serum IgM, But Not to Intestinal IgA, Production in Gnotobiotic Ig Allotype Chimeric Mice

23 August 2017

cites work

1 reference

The selection of marginal zone B cells differs from that of B-1a cells

21 January 2018

1 reference

The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes

21 January 2018

1 reference

The loss and gain of marginal zone and peritoneal B cells is different in response to relapsing fever and Lyme disease Borrelia

21 January 2018

1 reference

Cutting edge: the spirochetemia of murine relapsing fever is cleared by complement-independent bactericidal antibodies

21 January 2018

1 reference

Critical role for IgM in host protection in experimental filarial infection

21 January 2018

1 reference

Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).

21 January 2018

1 reference

21 January 2018

B-1 B cell development

1 reference

Increased Positive Selection of B1 Cells and Reduced B Cell Tolerance to Intracellular Antigens in c1q-Deficient Mice

21 January 2018

1 reference

The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells

21 January 2018

1 reference

The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice.

21 January 2018

1 reference

Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells

21 January 2018

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Restoration of natural IgM production from liver B cells by exogenous IL-18 improves the survival of burn-injured mice infected with Pseudomonas aeruginosa.

21 January 2018

1 reference

Generation of a complement-independent bactericidal IgM against a relapsing fever Borrelia

21 January 2018

1 reference

Evolution of vertebrate IgM: complete amino acid sequence of the constant region of Ambystoma mexicanum mu chain deduced from cDNA sequence

21 January 2018

1 reference

Basal B-cell receptor signaling in B lymphocytes: mechanisms of regulation and role in positive selection, differentiation, and peripheral survival

31 March 2020

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PI3 kinase signals BCR-dependent mature B cell survival

31 March 2020

1 reference

31 March 2020

Natural autoantibodies.

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The repertoire of serum IgM in normal mice is largely independent of external antigenic contact

31 March 2020

1 reference

Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response

31 March 2020

1 reference

The human IgM pentamer is a mushroom-shaped molecule with a flexural bias

31 March 2020

1 reference

Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophagesin vitro

31 March 2020

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IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo

31 March 2020

1 reference

IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells

31 March 2020

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Mannose-binding lectin engagement with late apoptotic and necrotic cells

31 March 2020

1 reference

Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin

31 March 2020

1 reference

Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis

31 March 2020

1 reference

Identification of TOSO/FAIM3 as an Fc receptor for IgM.

31 March 2020

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Identity of the elusive IgM Fc receptor (FcmuR) in humans

31 March 2020

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Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes

31 March 2020

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Unusual biochemical features and follicular dendritic cell expression of human Fcalpha/mu receptor

31 March 2020

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Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice

31 March 2020

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Cutting Edge: Selection of B Lymphocyte Subsets Is Regulated by Natural IgM

31 March 2020

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Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion

31 March 2020

1 reference

31 March 2020

Marginal-zone B cells

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Repertoire-based selection into the marginal zone compartment during B cell development

31 March 2020

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Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

31 March 2020

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Peritoneal B-2 cells comprise a distinct B-2 cell population with B-1b-like characteristics

31 March 2020

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Control of early viral and bacterial distribution and disease by natural antibodies

31 March 2020

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A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection

31 March 2020

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B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection

31 March 2020

1 reference

Dual role for B-1a cells in immunity to influenza virus infection

31 March 2020

1 reference

The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response

31 March 2020

1 reference

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae

31 March 2020

1 reference

Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity

31 March 2020

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The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

31 March 2020

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The absence of serum IgM enhances the susceptibility of mice to pulmonary challenge with Cryptococcus neoformans.

31 March 2020

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Improved survival of mice deficient in secretory immunoglobulin M following systemic infection with Cryptococcus neoformans

31 March 2020

1 reference

Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination

31 March 2020

1 reference

Parasite-specific IgM plays a significant role in the protective immune response to asexual erythrocytic stage Plasmodium chabaudi AS infection

31 March 2020

1 reference

A human monoclonal immunoglobulin M reduces bacteremia and inflammation in a mouse model of systemic pneumococcal infection

31 March 2020

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Natural human antibodies to pneumococcus have distinctive molecular characteristics and protect against pneumococcal disease

31 March 2020

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Secreted IgM enhances B cell receptor signaling and promotes splenic but impairs peritoneal B cell survival

31 March 2020

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Antigen-dependent B-cell development

31 March 2020

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Do developing B cells need antigen?

31 March 2020

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The role of the B cell receptor V region in peripheral B cell survival

31 March 2020

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Positive selection of B cells expressing low densities of self-reactive BCRs

31 March 2020

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Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study

31 March 2020

1 reference

Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck.

31 March 2020

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Peritoneal CD5+ B-1 cells have signaling properties similar to tolerant B cells

31 March 2020

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Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies.

31 March 2020

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Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM.

31 March 2020

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Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice

31 March 2020

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IgM reduction in systemic lupus erythematosus

31 March 2020

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High levels of circulating early apoptic peripheral blood mononuclear cells in systemic lupus erythematosus

31 March 2020

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Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men.

31 March 2020

1 reference

Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events

31 March 2020

1 reference

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes

31 March 2020

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Engulfment of apoptotic cells: signals for a good meal

31 March 2020

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The role of IgM antibodies in the recognition and clearance of apoptotic cells

31 March 2020

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A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions

31 March 2020

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C1q, autoimmunity and apoptosis

31 March 2020

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Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells

31 March 2020

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A novel subpopulation of B-1 cells is enriched with autoreactivity in normal and lupus-prone mice.

31 March 2020

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Class switching and consecutive loss of dsDNA-reactive B1a B cells from the peritoneal cavity during murine lupus development.

31 March 2020

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B1 cells promote pancreas infiltration by autoreactive T cells.

31 March 2020

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Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells

31 March 2020

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A role of IgM antibodies in monosodium urate crystal formation and associated adjuvanticity

31 March 2020

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Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury

31 March 2020

1 reference

Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction

31 March 2020

1 reference

Repeated B lymphocyte depletion with rituximab in rheumatoid arthritis over 7 yrs

31 March 2020

1 reference

Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study

31 March 2020

1 reference

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

31 March 2020

1 reference

B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice

31 March 2020

1 reference

B cell depletion reduces the development of atherosclerosis in mice

31 March 2020

1 reference

Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system

31 March 2020

1 reference

A Critical Role for Induced IgM in the Protection against West Nile Virus Infection

31 March 2020

1 reference

T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection

31 March 2020

1 reference

Essential role for humoral immunity during Ehrlichia infection in immunocompetent mice

31 March 2020

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Humoral immunity through immunoglobulin M protects mice from an experimental actinomycetoma infection by Nocardia brasiliensis.

31 March 2020

1 reference

Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens

31 March 2020

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Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion.

31 March 2020

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Naturally occurring immunoglobulin M antibodies: enhancement of phagocytic and microbicidal activities of human neutrophils against Toxoplasma gondii

31 March 2020

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Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response

31 March 2020

1 reference

The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice

31 March 2020

1 reference

Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice

31 March 2020

1 reference

12 December 2020

Effects of IGM-enriched solution on polymorphonuclear neutrophil function, bacterial clearance, and lung histology in endotoxemia.

1 reference

12 December 2020

Domain-switched mouse IgM/IgG2b hybrids indicate individual roles for C mu 2, C mu 3, and C mu 4 domains in the regulation of the interaction of IgM with complement C1q.

1 reference

12 December 2020

Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM

1 reference

12 December 2020

Direct evidence that J chain regulates the polymeric structure of IgM in antibody-secreting B cells

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12 December 2020

The role of antibodies in natural and acquired resistance of mice to vesicular stomatitis virus

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12 December 2020

Identifiers

DOI

10.1038/NRI2849

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23 August 2017

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