(Q37374645)

20 August 2017

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title

The IKK-related kinases: from innate immunity to oncogenesis (English)

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20 August 2017

author name string

Jean-François Clément

series ordinal

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20 August 2017

Sylvain Meloche

series ordinal

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20 August 2017

Marc J Servant

series ordinal

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20 August 2017

language of work or name

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1 September 2008

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20 August 2017

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20 August 2017

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20 August 2017

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20 August 2017

page(s)

889-899

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Inflammation and cancer: back to Virchow?

20 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Inflammation and cancer

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The IRF family transcription factors in immunity and oncogenesis

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Signaling pathways downstream of pattern-recognition receptors and their cross talk

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The IkappaB kinase - a bridge between inflammation and cancer

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

A cytokine-mediated link between innate immunity, inflammation, and cancer

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Oncogenic ras-induced expression of cytokines: a new target of anti-cancer therapeutics

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

NF-kappaB: linking inflammation and immunity to cancer development and progression

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Regulation and function of IKK and IKK-related kinases

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

NAK is an IkappaB kinase-activating kinase

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IRF-7 is the master regulator of type-I interferon-dependent immune responses

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IKKi/IKKϵ Plays a Key Role in Integrating Signals Induced by Pro-inflammatory Stimuli

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Genomic structure and functional characterization of the promoter region of human IkappaB kinase-related kinase IKKi/IKKvarepsilon gene.

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

NF-kappaB RelA phosphorylation regulates RelA acetylation

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Triggering the interferon antiviral response through an IKK-related pathway

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Differential activation of IFN regulatory factor (IRF)-3 and IRF-5 transcription factors during viral infection

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

A FADD-dependent innate immune mechanism in mammalian cells

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

VISA is an adapter protein required for virus-triggered IFN-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

NLRX1 is a regulator of mitochondrial antiviral immunity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Antiviral innate immunity pathways.

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Ral GTPases: corrupting the exocyst in cancer cells

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Distinct requirements for Ras oncogenesis in human versus mouse cells

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Species- and cell type-specific requirements for cellular transformation

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Nuclear factor-kappaB signature of inflammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-kappaB DNA-binding

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

NF-kappa B genes have a major role in inflammatory breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Targeting RAS signalling pathways in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Identification of TRAIL as an interferon regulatory factor 3 transcriptional target

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Apoptosis is promoted by the dsRNA-activated factor (DRAF1) during viral infection independent of the action of interferon or p53.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Single-stranded RNA viruses inactivate the transcriptional activity of p53 but induce NOXA-dependent apoptosis via post-translational modifications of IRF-1, IRF-3 and CREB

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

A new pathway of translational regulation mediated by eukaryotic initiation factor 3

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Interferon regulatory factor 3 activates p53-dependent cell growth inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

https://api.crossref.org/works/10.1038%2FCR.2008.273

1 reference

7 January 2021

Stat transcription factors in mammary gland development and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

The role of STATs in transcriptional control and their impact on cellular function

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

STAT1 as a key modulator of cell death

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Oncolytic activity of vesicular stomatitis virus is effective against tumors exhibiting aberrant p53, Ras, or myc function and involves the induction of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Systemic therapy of experimental breast cancer metastases by mutant vesicular stomatitis virus in immune-competent mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs

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https://api.crossref.org/works/10.1038%2FCR.2008.273

7 January 2021

Identifiers

DOI

10.1038/CR.2008.273

1 reference

20 August 2017

1 reference