(Q36767508)

16 August 2017

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title

Modulation of the immunological synapse: a key to HIV-1 pathogenesis? (English)

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16 August 2017

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Oliver T Fackler

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Olivier Schwartz

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Andres Alcover

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16 August 2017

publication date

1 April 2007

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Nature Reviews Immunology

16 August 2017

published in

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16 August 2017

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16 August 2017

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16 August 2017

page(s)

310-317

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Perils at mucosal front lines for HIV and SIV and their hosts

16 August 2017

cites work

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Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement

21 January 2018

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TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion

21 January 2018

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Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation

21 January 2018

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21 January 2018

1 reference

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

31 March 2020

1 reference

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

31 March 2020

1 reference

Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells

31 March 2020

1 reference

NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation

31 March 2020

1 reference

HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.

31 March 2020

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Human immunodeficiency virus long terminal repeat responds to T-cell activation signals

31 March 2020

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Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts

31 March 2020

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Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells

31 March 2020

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Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation

31 March 2020

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Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells

31 March 2020

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The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

31 March 2020

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In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline

31 March 2020

1 reference

Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4+ T Cells

31 March 2020

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HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues

31 March 2020

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Nonproliferating bystander CD4+ T cells lacking activation markers support HIV replication during immune activation

31 March 2020

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Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes

31 March 2020

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How T lymphocytes switch between life and death

31 March 2020

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T cell homeostasis in steady state and lymphopenic conditions

31 March 2020

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HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

31 March 2020

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Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators

31 March 2020

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HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

31 March 2020

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Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.

31 March 2020

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HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

31 March 2020

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Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.

31 March 2020

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Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway

31 March 2020

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Host factors regulating post-integration latency of HIV

31 March 2020

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HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse

31 March 2020

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The role of cell-to-cell transmission in HIV infection

31 March 2020

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Dangerous liaisons at the virological synapse

31 March 2020

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ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation.

31 March 2020

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Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse

31 March 2020

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The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity

31 March 2020

1 reference

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

31 March 2020

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

31 March 2020

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

31 March 2020

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Structure--function relationships in HIV-1 Nef.

31 March 2020

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Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

31 March 2020

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HIV/SIV escape from immune surveillance: focus on Nef

31 March 2020

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Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways

31 March 2020

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A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

31 March 2020

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The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells

31 March 2020

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Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes.

31 March 2020

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Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4+ T cells in a Nef-dependent manner in vitro and in vivo

31 March 2020

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Endothelial cells promote human immunodeficiency virus replication in nondividing memory T cells via Nef-, Vpr-, and T-cell receptor-dependent activation of NFAT.

31 March 2020

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Tuning immune responses: diversity and adaptation of the immunological synapse.

31 March 2020

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Regulation of Lck activity by CD4 and CD28 in the immunological synapse

31 March 2020

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CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

31 March 2020

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Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction

31 March 2020

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Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta

31 March 2020

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HIV-1 Nef increases T cell activation in a stimulus-dependent manner

31 March 2020

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The Nef protein of HIV-1 associates with rafts and primes T cells for activation

31 March 2020

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

31 March 2020

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Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation

31 March 2020

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Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes.

31 March 2020

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

31 March 2020

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Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation

31 March 2020

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Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

31 March 2020

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Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation

31 March 2020

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Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling

31 March 2020

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Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes.

31 March 2020

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Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivity

31 March 2020

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Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

31 March 2020

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HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells

31 March 2020

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Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation

31 March 2020

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Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes

31 March 2020

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Lentivirus Nef specifically activates Pak2.

31 March 2020

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Identification of the Nef-associated kinase as p21-activated kinase 2

31 March 2020

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Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

31 March 2020

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Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

31 March 2020

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Engaged and bystander T cell receptors are down-modulated by different endocytotic pathways

31 March 2020

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The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis

31 March 2020

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A WASp-binding type II phosphatidylinositol 4-kinase required for actin polymerization-driven endosome motility

31 March 2020

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A WASp homolog powers actin polymerization-dependent motility of endosomes in vivo.

31 March 2020

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Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP.

31 March 2020

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Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

31 March 2020

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Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

31 March 2020

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HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages

31 March 2020

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Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells

31 March 2020

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HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway.

31 March 2020

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Human immunodeficiency virus type 1 (HIV-1) Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors: involvement of Nef domains interacting with the cell endocytotic machinery

31 March 2020

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HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

31 March 2020

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Strength of signal: a fundamental mechanism for cell fate specification

31 March 2020

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Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

31 March 2020

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T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification

31 March 2020

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T cell activation determined by T cell receptor number and tunable thresholds.

31 March 2020

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Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy.

31 March 2020

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

31 March 2020

1 reference

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

31 March 2020

1 reference

Inefficient human immunodeficiency virus replication in mobile lymphocytes

31 March 2020

1 reference

nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes.

31 March 2020

1 reference

The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation

31 March 2020

1 reference

Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI2041

1 reference

release_u7qmud4pjbbw3ae5eps7v7mtdq

16 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/u7qmud4pjbbw3ae5eps7v7mtdq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference