(Q36751821)

English

Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle

scientific article published on 20 October 2015

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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author name string

Jennifer L Steiner

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Kristen T Crowell

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Scot R Kimball

3

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Charles H Lang

4

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Europe PubMed Central

PMC publication ID

16 August 2017

publication date

20 October 2015

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Europe PubMed Central

PMC publication ID

16 August 2017

American Journal of Physiology - Endocrinology and Metabolism

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Europe PubMed Central

PMC publication ID

16 August 2017

309

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Europe PubMed Central

PMC publication ID

16 August 2017

12

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Europe PubMed Central

PMC publication ID

16 August 2017

E981-94

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Europe PubMed Central

PMC publication ID

16 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4816198/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.

1 reference

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29 September 2017

Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways, and transcription factors

1 reference

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29 September 2017

Sepsis attenuates the anabolic response to skeletal muscle contraction

1 reference

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29 September 2017

Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways

1 reference

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29 September 2017

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

29 September 2017

Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency

1 reference

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Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies

1 reference

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29 September 2017

Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).

1 reference

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29 September 2017

Autophagy and skeletal muscles in sepsis

1 reference

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29 September 2017

Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness

1 reference

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29 September 2017

Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

1 reference

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29 September 2017

mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong?

1 reference

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29 September 2017

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

1 reference

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29 September 2017

Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique

1 reference

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29 September 2017

Local insulin-like growth factor I prevents sepsis-induced muscle atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

29 September 2017

Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

29 September 2017

REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

29 September 2017

Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle

1 reference

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29 September 2017

Acute alcohol intoxication increases REDD1 in skeletal muscle

1 reference

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29 September 2017

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

1 reference

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29 September 2017

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1 reference

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29 September 2017

Regulation of muscle protein synthesis during sepsis and inflammation

1 reference

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29 September 2017

Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha

1 reference

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29 September 2017

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

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29 September 2017

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

1 reference

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29 September 2017

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

1 reference

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29 September 2017

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

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29 September 2017

Alteration of somatotropic function by proinflammatory cytokines

1 reference

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29 September 2017

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

29 September 2017

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

29 September 2017

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

29 September 2017

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

29 September 2017

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

29 September 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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29 September 2017

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

1 reference

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29 September 2017

Amino acid-induced stimulation of translation initiation in rat skeletal muscle

1 reference

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29 September 2017

Ribosomal S6 kinase signaling and the control of translation

1 reference

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29 September 2017

Regulation of eIF-4E BP1 phosphorylation by mTOR.

1 reference

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29 September 2017

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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29 September 2017

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle

1 reference

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29 September 2017

Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

28 June 2018

Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

28 June 2018

IL-6-induced skeletal muscle atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

28 June 2018

Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

28 June 2018

REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

5 September 2018

Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

5 September 2018

Autophagy is required to maintain muscle mass.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816198

5 September 2018

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1 reference

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1 reference

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Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00264.2015

21 January 2018

Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/26487002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-binding protein ameliorates inhibition of skeletal muscle protein synthesis during sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26487002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal research. Harmonization of animal care and use guidance

1 reference

https://pubmed.ncbi.nlm.nih.gov/26487002

12 December 2020

based on heuristic

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beta-Adrenergic blockade during systemic inflammation: impact on cellular immune functions and survival in a murine model of sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26487002

12 December 2020

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Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/26487002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPENDO.00264.2015

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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