(Q35203303)

7 August 2017

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title

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis (English)

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7 August 2017

Zhiheng He

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7 August 2017

Andrew Bateman

series ordinal

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7 August 2017

publication date

19 August 2003

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Journal of Molecular Medicine

7 August 2017

published in

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

600-612

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Phosphorothioate oligodeoxynucleotides inhibit basic fibroblast growth factor-induced angiogenesis in vitro and in vivo

7 August 2017

cites work

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12 December 2020

Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts

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12 December 2020

Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival.

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12 December 2020

Growth factors in development, transformation, and tumorigenesis

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12 December 2020

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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12 December 2020

Identification of a membrane-associated receptor for transforming growth factor type E

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12 December 2020

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

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12 December 2020

Cutaneous wound healing

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12 December 2020

Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells

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12 December 2020

Structure and chromosomal location of the human granulin gene

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12 December 2020

Differential gene expression in synovium of rheumatoid arthritis and osteoarthritis

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12 December 2020

Granulins: the structure and function of an emerging family of growth factors

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12 December 2020

Gonadal steroid induction of structural sex differences in the central nervous system

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12 December 2020

Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle

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12 December 2020

Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor).

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12 December 2020

Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide

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12 December 2020

The role of the epidermal growth factor-like protein dlk in cell differentiation

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12 December 2020

Somatostatin-, vasoactive intestinal peptide-, and granulin-like peptides isolated from intestinal extracts of goldfish, Carassius auratus

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12 December 2020

Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo

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12 December 2020

Immunocytochemical localization of granulin-1 to mononuclear phagocytic cells of the teleost fish Cyprinus carpio and Carassius auratus

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12 December 2020

Focal adhesion kinase: protein interactions and cellular functions

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12 December 2020

The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system

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12 December 2020

Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium

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12 December 2020

Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins

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12 December 2020

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

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12 December 2020

Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics

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12 December 2020

Alterations in the responsiveness of senescent cells to growth factors

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12 December 2020

Production of transforming growth factor beta by human peripheral blood monocytes and neutrophils

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12 December 2020

Identifying marker genes in transcription profiling data using a mixture of feature relevance experts

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12 December 2020

Purification of granulin-like polypeptide from the blood-sucking leech, Hirudo nipponia

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12 December 2020

Activated human neutrophils release hepatocyte growth factor/scatter factor

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12 December 2020

The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth

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12 December 2020

Design and solution structure of a well-folded stack of two beta-hairpins based on the amino-terminal fragment of human granulin A

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor).

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12 December 2020

PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma

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12 December 2020

RNA expression patterns change dramatically in human neutrophils exposed to bacteria

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12 December 2020

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays

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12 December 2020

Isolation and structural determination of three peptides from the insect Locusta migratoria. Identification of a deoxyhexose-linked peptide

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12 December 2020

Modulation of microvascular growth and morphogenesis by reconstituted basement membrane gel in three-dimensional cultures of rat aorta: A comparative study of angiogenesis in Matrigel, collagen, fibrin, and plasma clot

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12 December 2020

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

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12 December 2020

Serological identification and expression analysis of gastric cancer-associated genes

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12 December 2020

Isolation and N-Terminal Sequence of Multiple Forms of Granulins in Human Urine

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12 December 2020

Granulin precursor gene: a sex steroid-inducible gene involved in sexual differentiation of the rat brain

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12 December 2020

Macrophages and angiogenesis

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12 December 2020

Gonadal steroids and neuronal plasticity. Studies in the adult rat hypothalamus.

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12 December 2020

Mapping of Grn, the gene encoding the granulin/epithelin precursor (acrogranin), to mouse chromosome 11

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12 December 2020

Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption

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12 December 2020

Differential gene expression profiling in human brain tumors

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12 December 2020

Cellular localization of gene expression for progranulin

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12 December 2020

Molecular mechanisms of "detachment-induced apoptosis--Anoikis".

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12 December 2020

A cysteine protease gene is expressed early in resistant potato interactions with Phytophthora infestans

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12 December 2020

Expression of vascular endothelial growth factor by synovial fluid neutrophils in rheumatoid arthritis (RA)

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12 December 2020

Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB

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12 December 2020

Structural and functional analysis of a promoter of the human granulin/epithelin gene

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12 December 2020

The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription

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12 December 2020

Purification and characterization of a novel transforming growth factor

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12 December 2020

Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray.

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12 December 2020

Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development

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12 December 2020

Epithelin mRNA expression in polycystic kidney disease

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12 December 2020

Granulins, a novel class of peptide from leukocytes

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12 December 2020

Dual control of cell growth by somatomedins and platelet-derived growth factor

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12 December 2020

Induction of granulin precursor gene expression by estrogen treatment in neonatal rat hypothalamus

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12 December 2020

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

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12 December 2020

High-density microarray analysis of hippocampal gene expression following experimental brain injury.

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12 December 2020

Mitosis in transition

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12 December 2020

Focal adhesion kinase in integrin-mediated signaling

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12 December 2020

Identification of eNAP-1, an antimicrobial peptide from equine neutrophils

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12 December 2020

The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro.

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12 December 2020

Pathogenesis of fibrosis: role of TGF-beta and CTGF.

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12 December 2020

Large induction of keratinocyte growth factor expression in the dermis during wound healing

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12 December 2020

In silico comparison of the transcriptome derived from purified normal breast cells and breast tumor cell lines reveals candidate upregulated genes in breast tumor cells

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12 December 2020

Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins

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12 December 2020

Progranulin is a mediator of the wound response

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12 December 2020

Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains

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12 December 2020

A novel growth stimulating activity from BRL-3A cell conditioned medium

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12 December 2020

Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats

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12 December 2020

Biological activities and signaling pathways of the granulin/epithelin precursor

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12 December 2020

Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.

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12 December 2020

Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis

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12 December 2020

Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins

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12 December 2020

Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS.

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12 December 2020

Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned vascular endothelial cells

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12 December 2020

Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease

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12 December 2020

Epithelial tissue-derived growth factor-like polypeptides

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12 December 2020

Isolation and primary structure of the three major forms of granulin-like peptides from hematopoietic tissues of a teleost fish (Cyprinus carpio).

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12 December 2020

Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line

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12 December 2020

Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

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12 December 2020

Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor)

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12 December 2020

Identification of genes involved in the host response to neurovirulent alphavirus infection

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12 December 2020

Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide.

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12 December 2020

Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468.

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12 December 2020

Biochemical analysis of the epithelin receptor

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12 December 2020

Transforming growth factor e: amino acid analysis and partial amino acid sequence

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12 December 2020

The complementary deoxyribonucleic acid sequence, tissue distribution, and cellular localization of the rat granulin precursor

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12 December 2020

Growth factors and cancer

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12 December 2020

Wound healing--aiming for perfect skin regeneration

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12 December 2020

Large-scale screen for genes involved in gonad development.

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12 December 2020

The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

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12 December 2020

Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin).

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12 December 2020

The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer.

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12 December 2020

Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus

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12 December 2020

The focal adhesion kinase--a regulator of cell migration and invasion

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12 December 2020

Cytokine pathways and joint inflammation in rheumatoid arthritis

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12 December 2020

10.1007/S00109-003-0474-3

Identifiers

DOI

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7 August 2017

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