(Q34642112)

3 August 2017

1 reference

title

Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes (English)

1 reference

3 August 2017

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Mark R Hutchinson

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Linda R Watkins

1 reference

3 August 2017

Annemarie Ledeboer

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3 August 2017

Kirk W Johnson

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3 August 2017

language of work or name

English

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publication date

1 July 2007

1 reference

Expert Opinion on Investigational Drugs

3 August 2017

published in

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3 August 2017

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3 August 2017

1 reference

3 August 2017

page(s)

935-950

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Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Challenges in the development of novel treatment strategies for neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

The induction of pain: an integrative review

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Neuronal plasticity: increasing the gain in pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Emerging trends in the pharmacotherapy of chronic pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.16.7.935

New treatments for neuropathic pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Opioids in chronic non-cancer pain: systematic review of efficacy and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Emerging therapies for neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Glia: a novel drug discovery target for clinical pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Neuroscience. The dark side of glia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Immune and glial cell factors as pain mediators and modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Role of the immune system in chronic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Glial activation and pathological pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Immune and inflammatory mechanisms in neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Potentiation of ibudilast inhibition of platelet aggregation in the presence of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Phosphodiesterase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Phosphodiesterases in the CNS: targets for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Preferential inhibition of human phosphodiesterase 4 by ibudilast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Effects of interferon-beta on microglial functions as inflammatory and antigen presenting cells in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Cyclic GMP/cyclic GMP-dependent protein kinase system prevents excitotoxicity in an immortalized oligodendroglial cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Effects of ibudilast on hippocampal long-term potentiation and passive avoidance responses in rats with transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Ibudilast, a phosphodiesterase inhibitor, protects against white matter damage under chronic cerebral hypoperfusion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Anti-inflammatory therapy by ibudilast, a phosphodiesterase inhibitor, in demyelination of twitcher, a genetic demyelination model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Gabapentin in the treatment of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Gabapentin for the Treatment of Postherpetic Neuralgia: A Randomized Controlled Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Gabapentin and postoperative pain--a systematic review of randomized controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Opioid Therapy for Chronic Pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Glia: novel counter-regulators of opioid analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

The involvement of glial cells in the development of morphine tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Neuronal protein kinase C gamma-dependent proliferation and hypertrophy of spinal cord astrocytes following repeated in vivo administration of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Transcriptional and translational regulation of glial activation by morphine in a rodent model of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

mu-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to mu-opioid receptor agonists: Comparison between etorphine and morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Functional reduction in mu-opioidergic system in the spinal cord under a neuropathic pain-like state following chronic ethanol consumption in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Comparative efficacy and safety of long-acting oral opioids for chronic non-cancer pain: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Opioids in neuropathic pain: clues from animal studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Opiate antinociception is altered by immunemodification: the effect of interferon, cyclosporine and radiation-induced immune suppression upon acute and long-term morphine activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Adenosine receptor activation and nociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Phosphodiesterase-4 as a potential drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Effects of phosphodiesterase inhibitors on cytokine production by microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: comparison with other types of cAMP-elevating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Glial modulating and neurotrophic properties of propentofylline and its application to Alzheimer's disease and vascular dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Propentofylline attenuates microglial reaction in the rat spinal cord induced by middle cerebral artery occlusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Pentoxifylline attenuates the development of hyperalgesia in a rat model of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

A selective phosphodiesterase IV inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

The Type IV phosphodiesterase inhibitor rolipram interferes with drug-induced conditioned place preference but not immediate early gene induction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Changes in evoked potentials and amino acid content during fluorocitrate action studied in rat hippocampal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Cerebrospinal fluid interleukin 8 concentrations and the subsequent development of postherpetic neuralgia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.7.935

10.1517/13543784.16.7.935

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference