(Q34465877)

2 August 2017

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title

Balancing natural killer cell activation through paired receptors (English)

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2 August 2017

Ludovic Martinet

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Mark J Smyth

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6 March 2015

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Nature Reviews Immunology

2 August 2017

published in

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

243-254

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Functions of natural killer cells

2 August 2017

cites work

1 reference

Controlling natural killer cell responses: integration of signals for activation and inhibition

21 January 2018

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Up on the tightrope: natural killer cell activation and inhibition

21 January 2018

1 reference

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

21 January 2018

1 reference

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

21 January 2018

1 reference

DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors

21 January 2018

1 reference

DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes

21 January 2018

1 reference

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

21 January 2018

1 reference

Biology and pathology of nectins and nectin-like molecules

21 January 2018

1 reference

Molecular mechanisms of natural killer cell activation in response to cellular stress

21 January 2018

1 reference

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

21 January 2018

1 reference

Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK-mediated killing of immature dendritic cells

21 January 2018

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Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)

21 January 2018

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Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226

21 January 2018

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CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain

21 January 2018

1 reference

Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor.

21 January 2018

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Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR.

21 January 2018

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A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

21 January 2018

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Vstm3 is a member of the CD28 family and an important modulator of T-cell function

21 January 2018

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To the editor: TIGIT versus CD226: hegemony or coexistence?

21 January 2018

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The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function

21 January 2018

1 reference

CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains

21 January 2018

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The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1.

21 January 2018

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DNAM-1 control of natural killer cells functions through nectin and nectin-like proteins

21 January 2018

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Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)

21 January 2018

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Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering

21 January 2018

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Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells

21 January 2018

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Formation and function of the lytic NK-cell immunological synapse

21 January 2018

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Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity

21 January 2018

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The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse.

21 January 2018

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Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization

21 January 2018

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Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions.

21 January 2018

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CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation

21 January 2018

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The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large

21 January 2018

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Physical and functional association of LFA-1 with DNAM-1 adhesion molecule

21 January 2018

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Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors.

21 January 2018

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The TIGIT/CD226 axis regulates human T cell function

21 January 2018

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The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans.

21 January 2018

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TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk.

21 January 2018

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T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling

21 January 2018

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Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

21 January 2018

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The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens

21 January 2018

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Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells

21 January 2018

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Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts.

21 January 2018

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Natural-killer cells and dendritic cells: "l'union fait la force".

21 January 2018

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Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response

21 January 2018

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DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction

21 January 2018

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T cell- and B cell-independent adaptive immunity mediated by natural killer cells.

21 January 2018

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Adaptive immune features of natural killer cells

21 January 2018

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Adaptive immune responses mediated by natural killer cells

21 January 2018

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Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function

21 January 2018

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Expansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

21 January 2018

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Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection

21 January 2018

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Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion

21 January 2018

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Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase

21 January 2018

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The expanding world of co-stimulation: the two-signal model revisited

21 January 2018

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ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

21 January 2018

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Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells

21 January 2018

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The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells

21 January 2018

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NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.

21 January 2018

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Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

21 January 2018

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Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers

21 January 2018

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Accelerated tumor growth in mice deficient in DNAM-1 receptor

21 January 2018

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ATM-dependent spontaneous regression of early Eμ-myc-induced murine B-cell leukemia depends on natural killer and T cells

21 January 2018

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DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases

21 January 2018

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NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma.

21 January 2018

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CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection

21 January 2018

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NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies

21 January 2018

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Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112

21 January 2018

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Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141

21 January 2018

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The human immunodeficiency virus type 1 Nef and Vpu proteins downregulate the natural killer cell-activating ligand PVR.

21 January 2018

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

21 January 2018

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Association between the CD226 rs763361 polymorphism and susceptibility to autoimmune diseases: a meta-analysis

21 January 2018

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Association of the CD226 single nucleotide polymorphism with systemic lupus erythematosus in the Chinese Han population

21 January 2018

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Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

21 January 2018

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Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients

21 January 2018

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Natural killer cells in human autoimmunity

21 January 2018

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MHC class I molecules and KIRs in human history, health and survival

21 January 2018

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NK cell MHC class I specific receptors (KIR): from biology to clinical intervention

21 January 2018

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Self-tolerance of natural killer cells

21 January 2018

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Building tolerance by dismantling synapses: inhibitory receptor signaling in natural killer cells

21 January 2018

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Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity

21 January 2018

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Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells

21 January 2018

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Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk

21 January 2018

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Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors

21 January 2018

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KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A * 11 while diminishing avidity for HLA-C

21 January 2018

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Understanding how combinations of HLA and KIR genes influence disease

21 January 2018

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HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection

21 January 2018

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Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes

21 January 2018

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Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation

21 January 2018

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Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis

21 January 2018

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Peptide antagonism as a mechanism for NK cell activation

21 January 2018

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Antagonizing inhibition gets NK cells going

21 January 2018

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NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection.

21 January 2018

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MHC class I-independent recognition of NK-activating receptor KIR2DS4

21 January 2018

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NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor

21 January 2018

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Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis

21 January 2018

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Association of DAP12 with activating CD94/NKG2C NK cell receptors

21 January 2018

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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

21 January 2018

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Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

21 January 2018

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HLA-E/β2 microglobulin overexpression in colorectal cancer is associated with recruitment of inhibitory immune cells and tumor progression

21 January 2018

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HLA-E: a novel player for histocompatibility

21 January 2018

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Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)

21 January 2018

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Development and function of CD94-deficient natural killer cells

21 January 2018

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CD94 is essential for NK cell-mediated resistance to a lethal viral disease

21 January 2018

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Imprint of human cytomegalovirus infection on the NK cell receptor repertoire

21 January 2018

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CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients.

21 January 2018

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Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts.

21 January 2018

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The CD94/NKG2C+ NK-cell subset on the edge of innate and adaptive immunity to human cytomegalovirus infection

21 January 2018

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Licensing of natural killer cells by host major histocompatibility complex class I molecules

21 January 2018

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Human NK cell education by inhibitory receptors for MHC class I.

21 January 2018

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SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

21 January 2018

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Unifying concepts of MHC-dependent natural killer cell education

21 January 2018

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Continuous engagement of a self-specific activation receptor induces NK cell tolerance

21 January 2018

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The speed of change: towards a discontinuity theory of immunity?

21 January 2018

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Intranodal interaction with dendritic cells dynamically regulates surface expression of the co-stimulatory receptor CD226 protein on murine T cells.

21 January 2018

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At the bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapy

21 January 2018

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Promoting regulation via the inhibition of DNAM-1 after transplantation

21 January 2018

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Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation

21 January 2018

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Tightly regulated induction of the adhesion molecule necl-5/CD155 during rat liver regeneration and acute liver injury

21 January 2018

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Transcriptional activation of the mouse Necl-5/Tage4/PVR/CD155 gene by fibroblast growth factor or oncogenic Ras through the Raf-MEK-ERK-AP-1 pathway.

21 January 2018

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CD155/PVR plays a key role in cell motility during tumor cell invasion and migration

21 January 2018

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The role of Necl-5 in the invasive activity of lung adenocarcinoma

21 January 2018

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Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma.

21 January 2018

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Interaction of cancer cells with platelets mediated by Necl-5/poliovirus receptor enhances cancer cell metastasis to the lungs.

21 January 2018

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The human immunodeficiency virus type 1 Vpr protein upregulates PVR via activation of the ATR-mediated DNA damage response pathway

21 January 2018

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The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.

21 January 2018

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Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells

21 January 2018

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The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM

21 January 2018

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Regulation of a late phase of T cell polarity and effector functions by Crtam

21 January 2018

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Nectin-like molecule-5/Tage4 enhances cell migration in an integrin-dependent, Nectin-3-independent manner.

21 January 2018

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Physical association between CD155 and CD44 in human monocytes

21 January 2018

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Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains

21 January 2018

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CRTAM Confers Late-Stage Activation of CD8+ T Cells to Regulate Retention within Lymph Node

21 January 2018

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Natural killer cell recognition of missing self

21 January 2018

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TACTILE becomes tangible: CD96 discloses its inhibitory peculiarities

31 March 2020

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Natural killer cells: a TACTILE restraint

31 March 2020

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Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion

31 March 2020

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Signaling complex formation of CD44 with src-related kinases

31 March 2020

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Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients

31 March 2020

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Natural killer cells expressing the KIR2DS1-activating receptor efficiently kill T-cell blasts and dendritic cells: implications in haploidentical HSCT

31 March 2020

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Peptide specificity in the recognition of MHC class I by natural killer cell clones

31 March 2020

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Specific engagement of the CD94/NKG2-A killer inhibitory receptor by the HLA-E class Ib molecule induces SHP-1 phosphatase recruitment to tyrosine-phosphorylated NKG2-A: evidence for receptor function in heterologous transfectants

31 March 2020

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Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells

31 March 2020

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12 December 2020

A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM)

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12 December 2020

Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor

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12 December 2020

Identification and molecular cloning of tactile. A novel human T cell activation antigen that is a member of the Ig gene superfamily

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12 December 2020

NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses

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12 December 2020

Identifiers

DOI

10.1038/NRI3799

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2 August 2017

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