(Q34443559)

2 August 2017

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title

Organelle-specific initiation of cell death pathways (English)

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2 August 2017

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Kroemer G

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2 August 2017

Ferri KF

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2 August 2017

publication date

1 November 2001

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2 August 2017

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

E255-63

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

2 August 2017

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The autophagosomal-lysosomal compartment in programmed cell death

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The mitochondrion: is it central to apoptosis?

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Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

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Caspase cleavage enhances the apoptosis-inducing effects of BAD.

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

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Two distinct pathways leading to nuclear apoptosis

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Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

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The proto-oncogene Bcl-2 and its role in regulating apoptosis

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Breaking the mitochondrial barrier

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The mitochondrion in apoptosis: how Pandora's box opens

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Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator

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7 January 2021

Mitochondrion as a novel target of anticancer chemotherapy

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7 January 2021

Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro

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7 January 2021

New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level

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7 January 2021

Death by design: the big debut of small molecules.

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7 January 2021

The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis

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7 January 2021

Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression

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7 January 2021

Facile detection of mitochondrial DNA mutations in tumors and bodily fluids

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7 January 2021

Mitochondrial DNA determines the cellular response to cancer therapeutic agents

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7 January 2021

The DNA damage response: putting checkpoints in perspective

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7 January 2021

Surfing the p53 network

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7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

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7 January 2021

Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria

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7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

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7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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7 January 2021

Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress

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7 January 2021

Irradiation of mitochondria initiates apoptosis in a cell free system

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7 January 2021

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

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7 January 2021

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

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7 January 2021

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

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7 January 2021

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

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7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

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7 January 2021

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

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https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

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7 January 2021

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

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7 January 2021

The versatility and universality of calcium signalling

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7 January 2021

T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis

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7 January 2021

Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor

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7 January 2021

Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells

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7 January 2021

Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.

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7 January 2021

The ins and outs of calreticulin: from the ER lumen to the extracellular space.

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7 January 2021

Apoptosis driven by IP(3)-linked mitochondrial calcium signals

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7 January 2021

Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

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https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

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https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

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https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Depletion of intracellular Ca2+ by caffeine and ryanodine induces apoptosis of chinese hamster ovary cells transfected with ryanodine receptor

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Control of apoptotic DNA degradation

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Induction of cell death by the lysosomotropic detergent MSDH.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Protection against oxidant-mediated lysosomal rupture: a new anti-apoptotic activity of Bcl-2?

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Cathepsin B-mediated activation of the proinflammatory caspase-11.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Age-related Macular Degeneration

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Lysosomal ceroid depletion by drugs: therapeutic implications for a hereditary neurodegenerative disease of childhood

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1)

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

PML is essential for multiple apoptotic pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Ikappa b-alpha, the NF-kappa B inhibitory subunit, interacts with ANT, the mitochondrial ATP/ADP translocator

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Stress management - heat shock protein-70 and the regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Heat-shock protein 70 antagonizes apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

PERK mediates cell-cycle exit during the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-E255

7 January 2021

Identifiers

DOI

10.1038/NCB1101-E255

1 reference

Dimensions Publication ID

2 August 2017

1036625499

0 references

1 reference