(Q34218011)

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Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

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Europe PubMed Central

PubMed publication ID

31 July 2017

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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phosphorylation

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1 reference

based on heuristic

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Francesco Giorgino

2

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F Giorgino

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

L J Goodyear

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

L A Sherman

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

J Carey

4

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

R J Smith

5

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Europe PubMed Central

PubMed publication ID

31 July 2017

G L Dohm

6

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Europe PubMed Central

PubMed publication ID

31 July 2017

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publication date

1 May 1995

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Europe PubMed Central

PubMed publication ID

31 July 2017

Journal of Clinical Investigation

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Europe PubMed Central

PubMed publication ID

31 July 2017

95

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Europe PubMed Central

PubMed publication ID

31 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

2195-2204

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

The insulin signaling system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

The dynamics of the glucose transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Insulin-receptor kinase activity of adipose tissue from morbidly obese humans with and without NIDDM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Diabetes-induced functional and structural changes in insulin receptors from rat skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Expression of insulin regulatable glucose transporters in skeletal muscle from type 2 (non-insulin-dependent) diabetic patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Exercise training increases glucose transporter protein GLUT-4 in skeletal muscle of obese Zucker (fa/fa) rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Activation of phosphatidylinositol 3-kinase by insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Changes in tyrosine phosphorylation of insulin receptors and a 170,000 molecular weight nonreceptor protein in vivo in skeletal muscle of streptozotocin-induced diabetic rats: effects of insulin and glucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Components of signaling pathways for insulin and insulin-like growth factor-I in muscle myoblasts and myotubes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Phosphatidylinositol 3-kinase: a novel effector

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

5 July 2018

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

28 October 2018

Abnormal Regulation of Protein Tyrosine Phosphatase Activities in Skeletal Muscle of Insulin-Resistant Humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=295829

28 October 2018

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin secretion, insulin resistance, and obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disposal of an oral glucose load in healthy subjects. A quantitative study

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrinsic differences of insulin receptor kinase activity in red and white muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of hypercortisolemia and diabetes on skeletal muscle insulin receptor function in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased expression of glucose transporter in muscle from insulin-resistant patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surgical treatment of obesity and its effect on diabetes: 10-y follow-up

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of phosphatidylinositol 3-kinase by insulin in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin binding and glucose uptake differences in rodent skeletal muscles

1 reference

https://pubmed.ncbi.nlm.nih.gov/7537758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI117909

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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