(Q33944673)

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Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

1 reference

based on heuristic

inferred from title

author name string

Ryan P Bender

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Neil Osheroff

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

publication date

22 May 2007

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Chemical Research in Toxicology

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

975-981

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.

1 reference

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Topoisomerase II and the etiology of chromosomal translocations

1 reference

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The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy

1 reference

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Beneficial effects of tea and its polyphenols against prostate cancer.

1 reference

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Etoposide, topoisomerase II and cancer

1 reference

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5 July 2018

Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group

1 reference

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5 July 2018

Biochemical and proteomics approaches to characterize topoisomerase IIalpha cysteines and DNA as targets responsible for cisplatin-induced inhibition of topoisomerase IIalpha.

1 reference

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N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison

1 reference

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Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

1 reference

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5 July 2018

Apoptosis induced by topoisomerase inhibitors

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5 July 2018

Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes

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DNA topoisomerase II as a target for cancer chemotherapy.

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Cellular roles of dna topoisomerases: a molecular perspective

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DNA topoisomerases: structure, function, and mechanism

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Leukemias related to treatment with DNA topoisomerase II inhibitors

1 reference

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5 July 2018

Tumor cell death induced by topoisomerase-targeting drugs.

1 reference

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5 July 2018

Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation

1 reference

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Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites.

1 reference

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The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues

1 reference

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5 July 2018

Topoisomerase II inhibitor-related acute myeloid leukaemia

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5 July 2018

Protection against breast cancer with genistein: a component of soy.

1 reference

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5 July 2018

Dietary flavonoids and the MLL gene: A pathway to infant leukemia?

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5 July 2018

Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

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5 July 2018

Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice

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Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins

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Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

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The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia

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Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group.

1 reference

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Cytotoxicity and DNA strand breaks induced by benzene and its metabolites in Chinese hamster ovary cells

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DNA topoisomerases

1 reference

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Structure and mechanism of DNA topoisomerase II

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Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

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Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster

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Genotoxicity of 1,4-benzoquinone and 1,4-naphthoquinone in relation to effects on glutathione and NAD(P)H levels in V79 cells

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Therapy-related acute nonlymphocytic leukemia with monocytic features and rearrangement of chromosome 11q.

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Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate

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Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.

1 reference

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1 reference

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Stability of the topoisomerase II closed clamp conformation may influence DNA-stimulated ATP hydrolysis

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1,4-Benzoquinone is a topoisomerase II poison

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Topoisomerase II poisoning by ICRF-193.

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29 October 2018

Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity

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The critical role of chromosome translocations in human leukemias.

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Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine

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A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

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Investigating the biological functions of DNA topoisomerases in eukaryotic cells

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Cell death induced by topoisomerase-targeted drugs: more questions than answers

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Identifiers

10.1021/TX700062T

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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