(Q33745071)

29 July 2017

title

p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. (English)

1 reference

29 July 2017

Jonathan Chernoff

0 references

Hoi Yee Chow

1 reference

29 July 2017

Dina Stepanova

series ordinal

1 reference

29 July 2017

Jennifer Koch

series ordinal

1 reference

29 July 2017

language of work or name

English

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publication date

2 November 2010

1 reference

29 July 2017

1 reference

29 July 2017

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29 July 2017

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29 July 2017

page(s)

e13791

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Creative Commons Attribution 4.0 International

29 July 2017

start time

2 November 2010

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

cites work

Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells

1 reference

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Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling

21 June 2018

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NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth

21 June 2018

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PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

21 June 2018

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PAK thread from amoeba to mammals

21 June 2018

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Pak protein kinases and their role in cancer

21 June 2018

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Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

21 June 2018

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Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2.

21 June 2018

1 reference

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Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

P21-activated kinase is required for mitotic progression and regulates Plk1.

21 June 2018

1 reference

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An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

21 June 2018

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The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion

21 June 2018

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Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac.

21 June 2018

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MEK/ERK regulates adherens junctions and migration through Rac1

21 June 2018

1 reference

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Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase

21 June 2018

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Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

21 June 2018

1 reference

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Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

21 June 2018

1 reference

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The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

21 June 2018

1 reference

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Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors

21 June 2018

1 reference

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21 June 2018

1 reference

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Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Biology of the p21-activated kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

A dominant-negative p65 PAK peptide inhibits angiogenesis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

p21-activated kinase links Rac/Cdc42 signaling to merlin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Tumorigenesis in neurofibromatosis: new insights and potential therapies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

21 June 2018

Neurofibromatosis type 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

A role for Pak protein kinases in Schwann cell transformation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970553

PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013791

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013791

A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013791

PAK promotes morphological changes by acting upstream of Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013791

Interdomain binding mediates tumor growth suppression by the NF2 gene product

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21072183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0013791

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference