(Q33251617)

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Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

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scholarly article

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Europe PubMed Central

PubMed publication ID

24 July 2017

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries (English)

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Europe PubMed Central

PubMed publication ID

24 July 2017

high-throughput screening

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7

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Europe PubMed Central

PubMed publication ID

24 July 2017

object named as

Adam Yasgar

6

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object named as

Ajit Jadhav

3

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Christopher P Austin

8

object named as

Christopher P Austin

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

5

object named as

Anton Simeonov

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

2

object named as

Douglas S Auld

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Europe PubMed Central

PubMed publication ID

24 July 2017

author name string

James Inglese

1

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Europe PubMed Central

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24 July 2017

Ronald L Johnson

4

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24 July 2017

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publication date

24 July 2006

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Europe PubMed Central

PubMed publication ID

24 July 2017

Proceedings of the National Academy of Sciences of the United States of America

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24 July 2017

103

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Europe PubMed Central

PubMed publication ID

24 July 2017

31

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Europe PubMed Central

PubMed publication ID

24 July 2017

11473-11478

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

Computational chemistry-driven decision making in lead generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

Statistical practice in high-throughput screening data analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

Enrichment of high-throughput screening data with increasing levels of noise using support vector machines, recursive partitioning, and laplacian-modified naive bayesian classifiers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

High-throughput assays for promiscuous inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

Assessing the minimum number of data points required for accurate IC50 determination

1 reference

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21 June 2018

Calculating the probability of detection for inhibitors in enzymatic or binding reactions in high-throughput screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

Evaluating real-life high-throughput screening data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

Streamlined system for purifying and quantifying a diverse library of compounds and the effect of compound concentration measurements on the accurate interpretation of biological assay results

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

NIH Molecular Libraries Initiative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

Pyruvate kinase: current status of regulatory and functional properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

Predicting therapeutic value in the lead optimization phase of drug discovery

1 reference

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21 June 2018

Novel receptor partners and function of receptor activity-modifying proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

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21 June 2018

Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus

1 reference

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21 June 2018

Crystal structure of the Src family tyrosine kinase Hck

1 reference

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21 June 2018

Purification and properties of pyruvate kinase from Bacillus stearothermophilus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

21 June 2018

Statistics of assay validation in high throughput cell imaging of nuclear factor kappaB nuclear translocation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1518803

31 October 2018

The minimum significant ratio: a statistical parameter to characterize the reproducibility of potency estimates from concentration-response assays and estimation by replicate-experiment studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16864780

12 December 2020

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Identifiers

10.1073/PNAS.0604348103

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

2006PNAS..10311473I

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

ResearchGate publication ID

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