(Q33229596)

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Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations

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Europe PubMed Central

PubMed publication ID

24 July 2017

Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

José Antonio Tercero

object named as

José Antonio Tercero

5

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Susan M. Gasser

6

object named as

Susan M Gasser

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

author name string

Jennifer A Cobb

1

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

Thomas Schleker

2

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

Vanesa Rojas

3

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

Lotte Bjergbaek

4

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Europe PubMed Central

PubMed publication ID

24 July 2017

publication date

1 December 2005

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

Genes & Development

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Europe PubMed Central

PubMed publication ID

24 July 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

24

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

3055-3069

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

The distribution of the numbers of mutants in bacterial populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Replication protein A phosphorylation and the cellular response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

DNA stimulates Mec1-mediated phosphorylation of replication protein A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

MEC1-dependent phosphorylation of yeast RPA1 in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Maintenance of genome stability in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Mrc1 transduces signals of DNA replication stress to activate Rad53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

The DNA replication checkpoint response stabilizes stalled replication forks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

21 June 2018

A central role for DNA replication forks in checkpoint activation and response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

31 October 2018

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

31 October 2018

Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1315408

31 October 2018

The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16357221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Rad53 kinase-dependent surveillance mechanism that regulates histone protein levels in S. cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/16357221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vivo replication origin of the yeast 2 microns plasmid

1 reference

https://pubmed.ncbi.nlm.nih.gov/16357221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork Barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/16357221

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1101/GAD.361805

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 July 2017

ResearchGate publication ID

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