(Q28513938)

25 January 2017

title

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity (English)

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25 January 2017

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H. Li

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25 January 2017

S. H. Li

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25 January 2017

H. Johnston

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25 January 2017

P. F. Shelbourne

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25 January 2017

X. J. Li

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25 January 2017

language of work or name

English

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publication date

1 August 2000

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25 January 2017

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25 January 2017

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25 January 2017

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25 January 2017

page(s)

385–389

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

25 January 2017

cites work

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7 January 2021

Neuropathological classification of Huntington's disease

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7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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7 January 2021

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

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7 January 2021

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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7 January 2021

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

1 reference

7 January 2021

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

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7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

7 January 2021

Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice

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7 January 2021

A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice

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7 January 2021

Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization

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7 January 2021

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

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7 January 2021

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

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7 January 2021

Alternative excitotoxic hypotheses

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7 January 2021

Huntington's disease, energy, and excitotoxicity

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7 January 2021

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

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7 January 2021

Differential loss of striatal projection neurons in Huntington disease

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7 January 2021

Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease

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7 January 2021

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

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7 January 2021

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

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7 January 2021

Interaction of huntingtin-associated protein with dynactin P150Glued

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7 January 2021

Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro.

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7 January 2021

Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism.

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7 January 2021

Glutamate accumulation into synaptic vesicles

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7 January 2021