(Q27919623)

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Mechanisms of caspase activation and inhibition during apoptosis

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26 November 2016

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Europe PubMed Central

Mechanisms of caspase activation and inhibition during apoptosis (English)

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PubMed publication ID

26 November 2016

apoptotic process

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1

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publication date

March 2002

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9

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3

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459-70

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Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

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Human ICE/CED-3 protease nomenclature

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Cytokinesis, apoptosis and survivin: three for tango?

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Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern

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Death receptors: signaling and modulation

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The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

1 reference

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Biochemical pathways of caspase activation during apoptosis

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Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.

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Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding

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Structural basis of caspase-7 inhibition by XIAP

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The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.

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Plant pathogens and integrated defence responses to infection

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IAP family proteins--suppressors of apoptosis

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

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Insights into programmed cell death through structural biology

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Structural biology. Controlling the caspases

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Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

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The Hallmarks of Cancer

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Understanding IAP function and regulation: a view from Drosophila

1 reference

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

1 reference

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Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

1 reference

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The NOD: a signaling module that regulates apoptosis and host defense against pathogens

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Programmed cell death in animal development

1 reference

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Livin, a novel inhibitor of apoptosis protein family member

1 reference

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

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Control of apoptosis and mitotic spindle checkpoint by survivin

1 reference

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

1 reference

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The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

1 reference

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

1 reference

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inferred from DOI database lookup

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

1 reference

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An exegesis of IAPs: salvation and surprises from BIR motifs

1 reference

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Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone

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An induced proximity model for caspase-8 activation.

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

1 reference

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Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

1 reference

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Dimer formation drives the activation of the cell death protease caspase 9

1 reference

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Structural basis for the activation of human procaspase-7

1 reference

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Structural basis for the inhibition of caspase-3 by XIAP

1 reference

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Caspase-9 and APAF-1 form an active holoenzyme

1 reference

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1 reference

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based on heuristic

inferred from DOI database lookup

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

1 reference

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Caspases: intracellular signaling by proteolysis

1 reference

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based on heuristic

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Caspase activation: the induced-proximity model

1 reference

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A structural view of mitochondria-mediated apoptosis

1 reference

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

1 reference

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based on heuristic

inferred from DOI database lookup

Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits

1 reference

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based on heuristic

inferred from DOI database lookup

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

1 reference

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based on heuristic

inferred from DOI database lookup

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

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based on heuristic

inferred from DOI database lookup

sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Caspase-9 can be activated without proteolytic processing

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

1 reference

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based on heuristic

inferred from DOI database lookup

NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

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inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

1 reference

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based on heuristic

inferred from DOI database lookup

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The atomic-resolution structure of human caspase-8, a key activator of apoptosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Structure and mechanism of interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila sickle is a novel grim-reaper cell death activator

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis of IAP recognition by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Autoproteolytic activation of pro-caspases by oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptosis in the nervous system

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900482-3

7 January 2021

based on heuristic

inferred from DOI database lookup

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