(Q27549397)

Spo11/DNA topoisomerase VI subunit A superfamily

1 reference

Spo11/DNA topoisomerase VI, subunit A, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Topoisomerase 6 subunit A/Spo11, TOPRIM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

catalytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

chromatin binding

IDA

1 reference

9 May 2019

Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

endodeoxyribonuclease activity, producing 3'-phosphomonoesters

IDA

1 reference

5 June 2018

Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23179&geneProductId=UniProtKB:P23179

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

isomerase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

protein binding

3 references

9 May 2019

Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

9 May 2019

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

9 May 2019

Interactions between Mei4, Rec114, and other proteins required for meiotic DNA double-strand break formation in Saccharomyces cerevisiae

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

14 February 2019

endodeoxyribonuclease activity, producing 3'-phosphomonoesters

endodeoxyribonuclease activity, producing 3'-phosphomonoesters

Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

nuclear chromosome

1 reference

9 May 2019

Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

TAS

nuclear chromosome

meiotic DNA double-strand break formation

biological process

DNA catabolic process, endonucleolytic

IGI

2 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

DNA metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

sporulation resulting in formation of a cellular spore

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

1 reference

9 May 2019

meiotic DNA double-strand break processing

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

reciprocal meiotic recombination

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

meiotic DNA double-strand break formation

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

9 May 2019

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

IGI

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23179

Spo11/DNA topoisomerase VI, subunit A, N-terminal

has part(s)

1 reference

Topoisomerase 6 subunit A/Spo11, TOPRIM domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference