(Q24629903)

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Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

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Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins (English)

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author name string

S H Ong

1

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Y R Hadari

2

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N Gotoh

3

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G R Guy

4

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J Schlessinger

5

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I Lax

6

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language of work or name

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publication date

22 May 2001

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Proceedings of the National Academy of Sciences of the United States of America

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98

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11

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6074-9

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

1 reference

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7 April 2017

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

1 reference

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7 April 2017

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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7 April 2017

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

1 reference

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7 April 2017

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

1 reference

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1 reference

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Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

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7 April 2017

NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

1 reference

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Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors

1 reference

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7 April 2017

Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts

1 reference

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

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Neurotrophin signal transduction in the nervous system

1 reference

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

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7 April 2017

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

1 reference

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1 reference

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7 April 2017

Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

1 reference

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7 April 2017

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

1 reference

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7 April 2017

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

1 reference

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7 April 2017

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

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7 April 2017

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1 reference

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7 April 2017

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

1 reference

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1 reference

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7 April 2017

Cellular survival: a play in three Akts

1 reference

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

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7 April 2017

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1 reference

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1 reference

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Endogenous and exogenous fibroblast growth factor 2 support survival of chick retinal neurons by control of neuronal neuronal bcl-x(L) and bcl-2 expression through a fibroblast berowth factor receptor 1- and ERK-dependent pathway

1 reference

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Brain-derived neurotrophic factor induces phosphorylation of fibroblast growth factor receptor substrate 2.

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The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.

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Functions of fibroblast growth factors in vertebrate development

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A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

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Trophic factors and neuronal survival

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Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

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Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

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1 reference

https://pubmed.ncbi.nlm.nih.gov/11353842

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1 reference

https://pubmed.ncbi.nlm.nih.gov/11353842

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1 reference

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Identifiers

10.1073/PNAS.111114298

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2001PNAS...98.6074O

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