(Q47371507)

English

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

scientific article published on 7 November 2017

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Europe PubMed Central

PubMed publication ID

15 January 2018

http://europepmc.org/abstract/MED/29114035

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein (English)

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Europe PubMed Central

PubMed publication ID

15 January 2018

http://europepmc.org/abstract/MED/29114035

author name string

Michael D Glidden

1

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7 June 2020

Khadijah Aldabbagh

2

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7 June 2020

Nelson B Phillips

3

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7 June 2020

Kelley Carr

4

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7 June 2020

Yen-Shan Chen

5

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7 June 2020

Jonathan Whittaker

6

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7 June 2020

Manijeh Phillips

7

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7 June 2020

Nischay Rege

9

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7 June 2020

Mamuni Swain

10

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7 June 2020

Yi Peng

11

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7 June 2020

Yanwu Yang

12

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7 June 2020

Michael C Lawrence

13

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7 June 2020

Vivien C Yee

14

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7 June 2020

Michael A Weiss

16

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7 June 2020

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publication date

7 November 2017

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15 January 2018

http://europepmc.org/abstract/MED/29114035

Journal of Biological Chemistry

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7 June 2020

293

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7 June 2020

1

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7 June 2020

47-68

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7 June 2020

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

1 reference

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Contribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.

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Pursuit of a perfect insulin.

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Characterization of Sizes of Aggregates of Insulin Analogs and the Conformations of the Constituent Protein Molecules: A Concomitant Dynamic Light Scattering and Raman Spectroscopy Study.

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Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors

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Initiation of human regular U-500 insulin use is associated with improved glycemic control: a real-world US cohort study

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Treatment of diabetic rats with insulin or a synthetic insulin receptor agonist peptide leads to divergent metabolic responses.

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Protective hinge in insulin opens to enable its receptor engagement

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Biophysical optimization of a therapeutic protein by nonstandard mutagenesis: studies of an iodo-insulin derivative

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Chemical synthesis of insulin analogs through a novel precursor

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Down-regulation of cyclin G2 by insulin, IGF-I (insulin-like growth factor 1) and X10 (AspB10 insulin): role in mitogenesis

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Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-I receptor

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How insulin engages its primary binding site on the insulin receptor

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Agonism and antagonism at the insulin receptor

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Insulin analog with additional disulfide bond has increased stability and preserved activity

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Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide

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Insulin analogs and cancer

1 reference

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Clinical use of U-500 regular insulin: review and meta-analysis

1 reference

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Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Glargine and detemir: Safety and efficacy profiles of the long-acting basal insulin analogs

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Measuring steady-state and dynamic endoplasmic reticulum and Golgi Zn2+ with genetically encoded sensors

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Supramolecular Protein Engineering: DESIGN OF ZINC-STAPLED INSULIN HEXAMERS AS A LONG ACTING DEPOT

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Integration, scaling, space-group assignment and post-refinement

1 reference

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An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design

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Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

1 reference

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Phasercrystallographic software

1 reference

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MCF-7 human mammary adenocarcinoma cells exhibit augmented responses to human insulin on a collagen IV surface

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Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS

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The human insulin superfamily of polypeptide hormones

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Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

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1 reference

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Insulin glulisine--a comprehensive preclinical evaluation

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Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly

1 reference

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Multiple gene copy number enhances insulin precursor secretion in the yeast Pichia pastoris

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate

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Insulin glulisine. Aventis Pharma.

1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Yeast secretory expression of insulin precursors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Signaling pathways in insulin action: molecular targets of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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The proprotein convertases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Insulin structure and stability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Evidence concerning insulin activity from the structure of a cross-linked derivative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Human insulin from recombinant DNA technology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Insulin biosynthesis: evidence for a precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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The structure of 2Zn pig insulin crystals at 1.5 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Reverse hydrophobic effects relieved by amino-acid substitutions at a protein surface.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

26 August 2018

Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Receptor binding redefined by a structural switch in a mutant human insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

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Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

26 August 2018

Altering the association properties of insulin by amino acid replacement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

26 August 2018

Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

26 August 2018

The A14 position of insulin tolerates considerable structural alterations with modest effects on the biological behavior of the hormone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

26 August 2018

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

26 August 2018

On the Role of the Proinsulin C-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766902

26 August 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M117.808626

21 January 2018

Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M117.808626

21 January 2018

Formation of the insulin-containing secretory granule core occurs within immature beta-granules

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retracted paper rattles Korean science

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and dynamics of a protein assembly. 1H-NMR studies of the 36 kDa R6 insulin hexamer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor binding and biologic activity of biosynthetic human insulin and mini-proinsulin produced by recombinant gene technology

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Semisynthesis and properties of some insulin analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretory expression and characterization of insulin in Pichia pastoris

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanism for the formation of fibrils from protein molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FDA perspective on peptide formulation and stability issues

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-ray structure of an unusual calcium site and the roles of zinc and calcium in the assembly, stability, and storage of the insulin hexamer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human insulin from a precursor overexpressed in the methylotrophic yeast Pichia pastoris and a simple procedure for purifying the expression product

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perturbation of insulin-receptor interactions by intramolecular hormone cross-linking. Analysis of relative movement among residues A1, B1, and B29

1 reference

https://pubmed.ncbi.nlm.nih.gov/29114035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M117.808626

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29114035%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29114035%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29114035%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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