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Hyperdiploidy defines a distinct cytogenetic entity of meningiomas

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Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Background

The most common chromosomal aberration found in meningiomas is monosomy 22. Progression and recurrence of meningiomas are usually associated with additional chromosome losses. Rarely, however, meningiomas have strongly hyperdiploid karyotypes with over 50 chromosomes; the objective of this study was to explore the cytogenetic and histopathologic patterns as well as the clinical significance of hyperdiploidy in meningiomas.

Methods

Within a series of 677 consecutive meningiomas, we identified a subgroup comprising 16 cases that display a strikingly uniform pattern of hyperdiploidy mostly without structural chromosome rearrangements, as shown by banding techniques and, in the single structurally aberrant case, spectral karyotyping.

Results

These meningiomas each have between 50 and 56 chromosomes, with trisomy 12 (14/16 cases), trisomy 20 (13/16 cases), trisomy 5 (12/16 cases), and trisomy 17 (10/16 cases). Histomorphologically, hyperdiploid meningiomas feature a heterogeneous phenotype. However, they are associated with a higher histological grade, and decreased expression of alkaline phosphatase as compared to meningiomas with typical karyotype. In two patients, recurrences were documented and three patients died of disease during the period of observation, indicating a worse prognosis of hyperdiploid than of cytogenetically typical meningiomas.

Conclusion

We conclude that hyperdiploidy constitutes a small but clinically relevant entity of biologically aggressive meningiomas, which are cytogenetically distinguishable from the majority of common-type meningiomas.

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Acknowledgments

We would like to thank S. Urbschat, S. Wemmert, U. Bechtel, and U. Lindemann for expert technical assistance and helpful discussions. Financial support was provided by the BMBF (grant No.01GR0453 to JR) and HomFor (grant No. 68-06). The work at the Max-Planck-Institute for Informatics was performed in the context of the BioSapiens Network of Excellence (EU contact no. LSHG-CT-2003-503265).

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Authors and Affiliations

  1. Neurosurgical Clinic, Saarland University, Homburg/Saar, Germany

    Ralf Ketter & Wolf-Ingo Steudel

  2. Institute of Neuropathology, Saarland University, Homburg/Saar, Germany

    Yoo-Jin Kim & Bernd F. M. Romeike

  3. Institute of Human Genetics, Saarland University, Homburg/Saar, Germany

    Simone Storck, Klaus D. Zang & Wolfram Henn

  4. Max Planck Institute for Informatics, 66123, Saarbruecken, Germany

    Jörg Rahnenführer

  5. Department of Neurosurgery, Saarland University, 66421, Homburg/Saar, Germany

    Ralf Ketter

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  1. Ralf Ketter
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Correspondence to Ralf Ketter.

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R. Ketter and Y.-J. Kim have contributed equally to this work.

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Ketter, R., Kim, YJ., Storck, S. et al. Hyperdiploidy defines a distinct cytogenetic entity of meningiomas. J Neurooncol 83, 213–221 (2007). https://doi.org/10.1007/s11060-006-9318-7

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  • DOI: https://doi.org/10.1007/s11060-006-9318-7

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