Abstract
The characteristics of aluminum and chromium binding to apotransferrin (apo-tf) have been investigated and compared. Both metal ions were taken up by human transferrin forming complexes with the maximum absorbances at 405 nm for chromium-transferrin (cr-tf) and 240 nm for aluminum-transferrin (Al-tf). In the presence of citric acid, chromium binding to transferrin is five times more than aluminum. The binding of aluminum or chromium to apo-transferrin was reduced by 18 and 22% in the presence of 200 ng/mL of iron. The binding of both metals to apo-tf appears to be pH dependent. In acidic pHs, less chromium and more aluminum binding occurred.
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Moshtaghie, A.A., Ani, M. & Bazrafshan, M.R. Comaprative binding study of aluminum and chromium to human transferrin. Biol Trace Elem Res 32, 39–46 (1992). https://doi.org/10.1007/BF02784585
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DOI: https://doi.org/10.1007/BF02784585