The model also suggests that selective mutations facilitate the development of cancer, so that the more selective mutations necessary for the development of�...
the numbers of neutral and selective mutations necessary and sufficient for cancer are positively correlated. What insights might we derive from these�...
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Exploring the Relationship between Neutral and. Selective Mutations in Cancer ... probability of developing cancer rises with the number of selective mutations.
Exploring the relationship between neutral and selective mutations in cancer. Authors: Carlo C. Maley. Carlo C. Maley. View Profile. , Stephanie Forrest.
The agent-based model allows us to examine the interactions of mutations critical for the development of cancer that are either evolutionarily neutral or�...
Clonal expansion via selective sweeps of cancer cell lineages with a favored mutation can also fix neutral alleles that are necessary for the cancer phenotype,�...
Jan 18, 2016 � Here we demonstrate that neutral tumor evolution results in a power-law distribution of the mutant allele frequencies reported by next-generation sequencing of�...
Apr 19, 2018 � Kimura's neutral theory argued that positive selection was not responsible for an appreciable fraction of molecular substitutions.
Nov 16, 2017 � In the context of cancer, a gene under positive selection will carry an extra complement of driver mutations in addition to neutral (passenger)�...
Neutral mutation rates in cancer cells are calculable from genomic data such as synonymous mutations, and selective pressures are calculable from rates of�...