May 28, 2021 � Our results indicate that the trigger, S184, and vMIA sites are the three major binding sites on the full-length BAX structure.
Nov 14, 2022 � Our results indicate that the trigger, S184, and vMIA sites are the three major binding sites on the full-length BAX structure. Moreover, the�...
May 28, 2021 � In this work, we employed cosolvent molecular dynamics simulation to detect the potential binding sites on the surface of BAX and performed a�...
A recent computational study on the pro-apoptotic Bax has provided information on the identification of prospective allosteric sites that can modulate�...
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BAX is a critical executioner of mitochondrial-regulated cell death through its lethal activity of permeabilizing the outer mitochondrial membrane.
This review presents recent advancements in elucidating the physiological and pharmacological modulation of BAX and in identifying potentially druggable binding�...
Jul 23, 2024 � While Bax was spontaneously poorly inserted in nanodiscs, co-synthesis with the mitochondrial receptor Tom22 stimulated Bax membrane insertion.
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We report the discovery of BTSA1, a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site�...
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This molecular dynamics study reveals that BIM SAHB forms a stable complex with BAX but it remains in a non-functional conformation.
Sep 20, 2011 � This article reports molecular dynamics simulations of monomeric Bax at 300, 400, and 500 K, focusing on the most relevant structural changes�...
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