Our results provide new insights into the interplay between the NF-κB and p53 pathway and help to gain a more comprehensive understanding of the crosstalk.
Jun 26, 2020 � We developed a systematic approach to identify potential interactions between the pathways. We perturbed NF-κB signaling by inhibiting IKK2, a critical�...
Jun 26, 2020 � Here, we developed a systematic approach to identify potential interactions between the pathways. We perturbed NF-κB signaling by inhibiting�...
a) Single cell trajectories are clustered into subpopulations with similar dynamics (upper left panel). For each cluster, a peak-based mean is calculated�...
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A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics. Click here to expand; Fabian Konrath, Anna Mittermeier�...
The dynamics of p53 expression provide a mechanism to increase differentiation between cellular stresses and specificity in appropriate responses.
This study quantified the dynamics of p53 in individual cells in response to UV and observed a single pulse that increases in amplitude and duration in�...
Loewer A (2020) A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics. PLoS Comput Biol 16, 1–27. 55 Hafner A�...
Feb 2, 2023 � In this review, we focused on how stresses are encoded into p53 dynamics and how the dynamics are decoded into cellular outcomes.
The cross-talk between Wnt and p53 signaling pathways allows to regulate each other. � Nutlin can able to switch on the somitogenesis at low Axin2 level. � Excess�...
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