Ani's first rise to prominence was in the 400s AD. At this time, it was a hilltop fortress that belonged to the Armenian Kamsarakan Dynasty; by the 800s, however, the Kamsarakan possessions in Eastern Anatolia had merged with the Bagratid Dynasty. In 961, King Ashot III moved the Armenian capital to Ani, and Armenian Catholics followed. Consequently, the city became the undisputed center of Armenia and grew rapidly until, by the eleventh century, there were more than 100,000 citizens. At its height, the city became known as the City of Forty Gates and the City of a Thousand Churches.

However, following the death of King Gagik in 1020, Armenian power was split between two sons and the golden age ended. The son who controlled Ani, attempting to prevent invasion, named the Byzantine Emperor his heir; eventually, though, the Byzantine Emperor stated his claim upon the city. The new king of Ani tried to keep his city independent, but after three years of military defeats and a pro-Byzantine uprising, Ani surrendered and the Byzantines established control.

The Byzantines, however, had wasted their time and effort, as in 1064 the Seljuk Turks took the city and massacred the populace. The city of Ani survived for another 650 years, but it was now a provincial town at the edge of competing empires. The Seljuk Turks passed possession of the city to Kurdish Shaddadids; they were attacked repeatedly by the neighboring Georgian Empire at the behest of Ani's unruly Christian population. The Shaddadids were conquered in 1199 by Queen Tamar of Georgia, and the Zakarid Dynasty of Ani was established. The city prospered once again, but was devastated this time in 1236 by the invading Mongol Hordes. The Zakarids continued to govern the city as the vassals of various Turkic and Persian Empires, culminating with the Ottomans, but Ani gradually faded into uninhabited ruins.

In the late 1800s, the Russian Empire took control of Kars and surrounding areas. The Saint Petersburg Academy of Sciences oversaw a large archaeological and restorative effort until the Russian Revolution in 1917. Russian scientists succeeded in setting up a huge museum on-site, principally in the Minuchihr Mosque.

After the Russian Revolution and the founding of the Republic of Armenia, the Ottoman military drove east into former Russian territories with the intention of seizing the region and getting rid of the ethnic Armenians. The Russian-led archaeologists did what they could to salvage remains of the ancient city and fled to modern-day Armenia. During the Turkish War of Independence, the Grand National Assembly of Turkey ordered the Eastern Front commander that the "monument of Ani be wiped off the face of the earth." The commander did not obey, fortunately, so the monuments of Ani remain. On the other hand, however, Russian excavations and repairs were undone, and the site languished under what can be most favorably described as neglect.

From 1585, when the Ottomans seized Kars Province, Ani has been on the edge of one of the most hostile borders in the world: Turkey and the Soviet Union (and since 1991, Armenia). Ani was within a Turkish military zone that precluded tourism. However, things have cooled down between Turkey and Armenia in more recent times, and militant Turkish opposition to acknowledging the ruins as a major tourist point of interest has subsided. There is a sign outside the main city gate that lists all of the approximately fifteen empires that have controlled the region; however, it does not mention the Armenians who built the city and are at the center of its history. The border remains closed and is visible from the ruins, but anyone can visit Ani without any sort of permit, and photography restrictions are a thing of the past. Although the Turkish government makes friendly noises about preservation, restoration, and excavation, it still receives low marks from international NGOs.

Ani's climate is hemiboreal, with short and mild summers but extremely harsh winters.

Summers (Jul-Aug), which have warm daytime temperatures, are the best time to visit, although they still have chilly to cold nights. Winters (Nov-Mar) are frigid and snowy. Spring and fall are both short and cool. Rain and snow are both frequent, with rain showers being especially frequent through spring, regularly bringing hail.

For more detailed information, the nearest city, Kars, has a similar climate and more information on its page.

• Ministry of Cultyre and Tourism website for Ani

As of February 2023, a bus leaves from Kars in front of the Gazi Ahmet Muhtar Paşa Konağı at 10:00 and returns at 13:30 in summer. In winter, departure is at 09:00 and return 12:45. Staff there can confirm the correct departure time (but only in Turkish).

If you want to hire a taxi for the day, ask at your hotel in Kars; expect to pay 500 TL (four people, Feb 2023) for a five hour trip, including two hours' driving time and 2 hours and a half to 3 hours at Ani. If you're not staying the night before in Kars, just look around downtown early in the morning for any backpacker or ask in hotel lobbies—virtually all travelers visiting Kars go to Ani, so you shouldn't have any trouble finding a ride in summer. The rides often leave from the small parking lot with shuttle rides to/from the main bus station.

There are virtually no tourists in Kars during the winter, so you may have to charter a taxi alone.

On many maps, there is a road to Ani marked about half way between Diğor and Kars; this road does not seem to exist and if comıng through Diğor you're better off taking the new road rıght outside Diğor (not signposted to Ani but is immediately after the sign to Kars when heading NW out of Diğor).

Even more preferable is the road from Kars to Ani, a four lane highway that leads directly to Ani.

If you're on a tight budget, you can try hitch-hiking from Kars. You will need to walk about 2 km out of Kars to the cross section where the road heads toward Ani. (There are sufficient street signs to find it.) There is limited traffic going in the direction of Ani, but eventually a local will stop for you. There is, of course, a matter of luck, but roughly 1 in 12 cars will give you a ride—don't hitch-hike if you're short on time, as it could take you four hours to get from Kars to Ani!