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High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene. This gene encodes a protein that belongs...

caused by a loss of function (LOF) mutation in the High mobility AT-hook 2 (HMGA2) gene, spanning 12.1Kb from 44,709,089 bp to 44,721,236 bp that removes...

rearrangements of the ALK gene, and occasionally with rearrangements of the HMGA2 gene. Tenosynovial giant cell tumor (not a sarcoma, but a non-metastasizing...

suggests the involvement of other unknown genes. Chromosomal imbalances of HMGA2 (high mobility AT-hook 2) located on chromosome 12 chromosome have been...

oncogene, high mobility group A2 (HMGA2), has also been identified as a target of let-7. Let-7 directly inhibits HMGA2 by binding to its 3'UTR. Removal...

(concurrently and independently of Alfredo Fusco), that fusion proteins between HMGA2 and other C terminal peptides (following chromosomal translocation) can...

decreased in cancers, rather than increased. HMGA2 protein could also have an effect on DNA-PKcs. HMGA2 delays the release of DNA-PKcs from sites of double-strand...

chromosomal architecture (caused by inappropriate expression of proteins such as HMGA2 or HMGA1). Each of these alterations regulates gene expression without altering...

the species became distinct. Genes for beak shape (ALX1) and beak size (HMGA2) have been determined to be crucial in separating the hybridized species...

PMID 12441356. Lemke I, Rogalla P, Grundmann F, et al. (2003). "Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid...

intermediate size and shape. IGF1R (Insulin-like growth factor 1 receptor) and HMGA2 (High-mobility group AT-hook 2) are incomplete dominant with delicate dwarfs...

ENSG00000137309 AT hook Known motif – In vivo/Misc source [361] WATTWW HMGA2 ENSG00000149948 AT hook Known motif – In vivo/Misc source [362] ATATTSSSSDWWAWT...

Marina; Payen, Emmanuel (September 16, 2010). "Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia". Nature. 467 (7313):...

altering the chromatin architecture". Mammals have two orthologs: HMGA1 and HMGA2. In mouse embryonic stem cells it has been demonstrated that both HMGA proteins...

CDK4 genes, this band 13–15 chromosome area also contains the TSPAN31 and HMGA2 genes which, when overexpressed, are associated with various tumors and/or...

recurrence and it is currently regarded as a non-metastasizing benign tumor. HMGA2 rearrangement by translocation t(12;21)(q15;q21.1) by translocation t(11;12)(q23;q15)...

Hehir K, Fusil F, et al. (September 2010). "Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia". Nature. 467 (7313):...

double-strand break and PARP-1 was involved in replacing histone H1 by HMGB1/HMGA2, which can promote transcription. Topo IIβ and PARP-1 increased at the site...

inactivate Rb family proteins. p16Ink4a and p19Arf expression are inhibited by Hmga2-dependent chromatin regulation. Many young adult stem cells are quiescent...

Papillary thyroid carcinoma commonly metastasizes to cervical lymph nodes. HMGA2 has been proposed as a marker to identify malignant tumors. Treatment is...